FR252921, a novel immunosuppressive agent isolated from Pseudomonas fluorescens no. 408813. I. Taxonomy,fermentation, isolation,physico-chemical properties and biological activities of FR252921, FR252922 and FR256523 |
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| Authors: | Fujine Kiyotaka Tanaka Miho Ohsumi Keisuke Hashimoto Michizane Takase Shigehiro Ueda Hirotsugu Hino Motohiro Fujii Takashi |
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| Affiliation: | Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. kiyotaka_fujine@po.fujisawa.co.jp |
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| Abstract: | Novel immunosuppressive agents, FR252921, FR252922 and FR256523 were isolated from the cultured broth of a bacterial strain No. 408813. The strain was identified Pseudomonas fluorescens from morphological and physiological characteristics. FR252921, FR252922 and FR256523, novel compounds containing macrolactone ring, showed immunosuppressive activity against murine splenocyte proliferation stimulated with lipopolysaccharide (LPS) or anti-CD3 mAb in vitro. |
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