| 原发性高血压的遗传异质性研究 |
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| 引用本文： | 龚瑶琴,郑红,陈丙玺,窦效伟,孙德成. 原发性高血压的遗传异质性研究[J]. 山东大学学报(医学版), 1994, 0(1) |
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| 作者姓名： | 龚瑶琴 郑红 陈丙玺 窦效伟 孙德成 |
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| 作者单位： | 济南市中心医院 |
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| 摘 要： | 用分离分析方法对１６１个原发性高血压患者核心家系进行了遗传异质性分析。结果表明原发性高血压存在遗传异质性，有些家系为常染色体显性遗传，外显不全，外显率为８８．１％；有些家系为散发的。本组家系中，常染色体显性外显不全家系占８２．８％，散发家系占１７．１２％。
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| 关 键 词： | 高血压；分离分析；遗传异质性；常染色体显性遗传 |
GENETIC HETEROGENEITY OF ESSENTIAL HYPERTENSION |
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| Gong Yaoqin,et al. GENETIC HETEROGENEITY OF ESSENTIAL HYPERTENSION[J]. Journal of Shandong University:Health Sciences, 1994, 0(1) |
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| Authors: | Gong Yaoqin et al |
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| Abstract: | Segregation analysis was performed on 161 nuclear families ascertained through 95 index patients with essential hypertension. The frequent vertical transmission and high segregation ratio suggest an autosomal dominant inheritance in the familial essential hypertension. Affected offsprings with one affected parent were compatible with autosomal dominance inheritance of incomplete penetrance (88. 1%). Affected offsprings from normal by normal matings were largely due to autosomal dominant inheritance,with 23.4% of sporadic cases. The overall genetic constitution is sporadic cases 17. 2%, autosomal dominance 82. 8%. |
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| Keywords: | Hypertension Segregation analysis Genetic heterogeneity Autosomal dominant inheritance |
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