散发性戊型肝炎病理特征的初步观察

目的：观察散发性戊型肝炎的病理特征。方法：收取10例散发性戊型肝炎患者的肝活检标本作病理组织学检查（通过光镜和电镜）。结果：6例急性黄疸型戊型肝炎和3例淤胆型戊型肝炎突出表现为肝细胞气体细胞气球样变和胆汁郁积，并见到淋巴细胞与变性肿胀肝细胞的紧密接触以及凋亡小体，支持戊型肝炎的免疫发病观点，1例亚急性重型戊型肝炎肝细胞大片坏死，但未完全崩解，而且残留部分变性肿胀肝细胞，B超观察肝脏外形一直未见缩小，与亚生重型乙型肝炎的病理改变不尽相同，各临床型肝炎均未见到肝星状细胞增多及胶原增生，似可为戊型肝炎不易转慢性提供佐证。结论：研究散发性戊型肝炎的病理特征有助于阐明其发病机制。

Pathologic features of sporadic hepatitis E

Objective To investigate the pathologic features of sporadic hepatitis E. Methods 10 liver biopsy specimens from patients with sporadic hepatitis E were studied by histopathology and electronmicroscopy.Results Ballooning degeneration of hepatocytes and variable degrees of cholestasis were found in acute and cholestatic hepatitis. Lymphocytes aggregation in portal tracts and close contact with hepatocytes were observed. In subacute severe hepatitis, there was significant multilobular or massive necrosis, whereas some degenerated hepatocytes still remained. Proliferation of hepatic fat-storing cells and deposited collagen fiber were not seen in all specimens which usually implicate a course toward chronicity and fibrosis.Conclusion The study of histopathology may be helpful in understanding the pathogenesis of sporadic hepatitis E.