肿瘤患者与正常人血小板表面粘附蛋白表达异同的临床观察及意义

目的观察恶性肿瘤患者血小板粘附分子的表达和血小板激活状态,探讨血小板功能异常与肿瘤发展的规律,为临床治疗提供依据。方法采用流式细胞术对５０例健康志愿者和１８１例恶性肿瘤患者血小板表面抗原的表达进行检测,对比正常人与早、中晚期肿瘤患者血小板粘附分子表达和血小板激活状态的异同。结果与正常人相比,肿瘤患者血小板ＣＤ４２ａ的表达减少,ＴＳＰ和ＣＤ３６的表达增强,ＣＤ３６＋ＴＳＰ＋、ＣＤ３６＋ＴＳＰ－、ＣＤ９＋、ＣＤ３１＋、ＣＤ６２＋ＣＤ６３－、ＣＤ６２＋ＣＤ６３＋、ＣＤ６２－ＣＤ６３＋血小板的比例增加。中晚期与早期肿瘤患者间的上述差异很明显;早期肿瘤患者与正常人间的差异则不显著;肿瘤患者血小板ＣＤ４１的表达与正常人相比未显示不同。结论肿瘤患者尤其是中晚期肿瘤患者血小板粘附分子的表达和释放增加,处于激活状态

Clinical observation on the adhesion molecule expression and functional study of platelets in cancer patients

Objective To investigate adhesion molecule expression and functional status of platelets in cancer patients and their relation to cancer progression. Methods Using flow cytometry to measure the expression of surface antigens and functional status of platelets in 50 healthy donors and 181 cancer patients. Results Comparing with normal donors, the expression of CD42a in cancer patients decreased, and that of TSP and CD36 increased. The number of platelets with CD36 TSP , CD36 TSP -, CD9 , CD31 , CD62 CD63 -, CD62 CD63 , CD62 -CD63 phenotypes also increased. There was significant difference between patients in early stage and those in advanced stage, but there was no significant difference between the patients in early stage and healthy donors. The expression of CD41 did not change in cancer patients.Conclusion In cancer patients, especially in the advanced stage of the disease, the expression of the adhesion molecules on platelets and their released products increase, indicative of an activated state of the platelets.