| CYP2D6、GSTM1遗传多态性与肺癌易感性关系 |
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| 作者姓名： | Gao J Ren C Zhang Q |
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| 作者单位： | 江苏镇江医学院卫生学教研室,中山医科大学公共卫生学院分子毒理研究室 |
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| 摘 要： | 目的探讨中国汉族广东籍人群中ＣＹＰ２Ｄ６、ＧＳＴＭ１的遗传多态性与肺癌易感性关系。方法采用病例—对照研究方法,用ＰＣＲ检测ＣＹＰ２Ｄ６、ＧＳＴＭ１的基因型,限制性酶切电泳鉴定ＣＹＰ２Ｄ６点突变。结果病例组与对照组间未发现ＣＹＰ２Ｄ６多态性分布差异,而ＧＳＴＭ１多态性存在分布差异,病例组为５８．７％,对照组为３５．７％（Ｐ＜０．０５）,ＯＲ值为２．５６（１．１１－２．４４）。结论ＣＹＰ２Ｄ６Ｇ－Ａ突变与肺癌易感性未见有联系,ＧＳＴＭ１－／－型个体患肺癌易感性增高
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| 关 键 词： | 肺肿瘤 疾病易感性 细胞色素p450 基因型 多态现象（遗传学） |
CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility |
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| Gao J,Ren C,Zhang Q.CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility[J].Chinese Journal of Oncology,1998,20(3):185-186. |
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| Authors: | Gao J Ren C Zhang Q |
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| Institution: | Department of Hygiene, Zhenjiang Medical College. |
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| Abstract: | OBJECTIVE: To evaluate the relationship between CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility among Cantonese in China. METHODS: In a case-control study, PCR was used to identify CYP2D6 and GSTM1 genotypes and restriction enzyme BstNI was used to identify a specific point mutation of CYP2D6. RESULTS: Between lung cancer patient group and normal control group CYP2D6 genetic polymorphism did not show frequency distribution differences but that of GSTM1 did (58.7% n = 46, 35.7%, n = 70, P < 0.05) OR = 2.56(1.11-2.44). CONCLUSION: There is no association between CYP2D6 G-A mutation and lung cancer susceptibility, while individuals with GSTM1 -/- genotype are susceptible to lung cancer. |
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| Keywords: | Lung neoplasms Disease susceptibility Cytochrome p450 Genotype Polymorphism(Genetics) |
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