周围型肺癌CT征象与p53蛋白及增殖细胞核抗原表达间关系的研究

目的研究周围型肺癌ＣＴ征象与ｐ５３蛋白及增殖细胞核抗原（ＰＣＮＡ）表达间的关系。方法运用ＳＰ免疫组化法,检测３２例经病理证实的周围型肺癌组织中ｐ５３蛋白及ＰＣＮＡ的表达,并回顾性分析其与术前ＣＴ征象间的关系。结果ｐ５３蛋白、ＰＣＮＡ表达与瘤体大小、深分叶征、空洞、胸膜凹陷征、纵隔淋巴结转移有关,与毛刺征无关。结论周围型肺癌ＣＴ征象中,瘤体直径＞３ｃｍ,或出现深分叶征、空洞、胸膜凹陷征、纵隔淋巴结转移者,具有相对更高的恶性程度,肿瘤细胞的增殖更为活跃。

Study on the correlation between CT features and expression of p53 protein and PCNA in peripheral lung cancer

Objective To investigate the correlation between CT features and expression of p53 protein and PCNA in peripheral lung cancer. Methods The expression of p53 protein and PCNA was examined by means of SP immunohistochemical technique in 32 cases of peripheral lung cancer proved by pathology; the relationship between the results and preoperative CT features was analyzed retrospectively. Results The expression of p53 protein and PCNA was correlated with tumor size, deep lobulation, frank cavitation, pleural indentation and mediastinal lymph node metastasis, but not with spiculation. Conclusion The CT features of peripheral lung cancer with diameter more than 3 cm, deep lobulation, frank cavitation, pleural indentation or mediastinal lymph node metastasis indicate higher degree of malignancy and proliferative activity of tumor cells.