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周围型肺癌CT征象与p53蛋白及增殖细胞核抗原表达间关系的研究
引用本文:Chen J,Zhang H,Huang X. 周围型肺癌CT征象与p53蛋白及增殖细胞核抗原表达间关系的研究[J]. 中华肿瘤杂志, 1998, 20(5): 361-364
作者姓名:Chen J  Zhang H  Huang X
作者单位:第四军医大学唐都医院介入放射科,解放军第九一医院胸外科
摘    要:目的研究周围型肺癌CT征象与p53蛋白及增殖细胞核抗原(PCNA)表达间的关系。方法运用SP免疫组化法,检测32例经病理证实的周围型肺癌组织中p53蛋白及PCNA的表达,并回顾性分析其与术前CT征象间的关系。结果p53蛋白、PCNA表达与瘤体大小、深分叶征、空洞、胸膜凹陷征、纵隔淋巴结转移有关,与毛刺征无关。结论周围型肺癌CT征象中,瘤体直径>3cm,或出现深分叶征、空洞、胸膜凹陷征、纵隔淋巴结转移者,具有相对更高的恶性程度,肿瘤细胞的增殖更为活跃。

关 键 词:肺肿瘤/放射摄影术  肺肿瘤/病理学  断层摄影术.X线计算机  p53蛋白增殖细胞核抗原  免疫组织化学

Study on the correlation between CT features and expression of p53 protein and PCNA in peripheral lung cancer
Chen J,Zhang H,Huang X. Study on the correlation between CT features and expression of p53 protein and PCNA in peripheral lung cancer[J]. Chinese Journal of Oncology, 1998, 20(5): 361-364
Authors:Chen J  Zhang H  Huang X
Affiliation:Department of Interventional Radiology, Tangdu Hospital, Fourth Military Medical University, Xian.
Abstract:Objective To investigate the correlation between CT features and expression of p53 protein and PCNA in peripheral lung cancer. Methods The expression of p53 protein and PCNA was examined by means of SP immunohistochemical technique in 32 cases of peripheral lung cancer proved by pathology; the relationship between the results and preoperative CT features was analyzed retrospectively. Results The expression of p53 protein and PCNA was correlated with tumor size, deep lobulation, frank cavitation, pleural indentation and mediastinal lymph node metastasis, but not with spiculation. Conclusion The CT features of peripheral lung cancer with diameter more than 3 cm, deep lobulation, frank cavitation, pleural indentation or mediastinal lymph node metastasis indicate higher degree of malignancy and proliferative activity of tumor cells.
Keywords:Lung neoplasms/radiography Lung neoplasms/pathology Tomography   X ray computed p53 protein Proliferating cell nuclear antigen Immunohistochemistry  
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