| PI3K/Akt信号传导通路在肿瘤发生发展及治疗中的作用 |
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| 引用本文： | 徐利本,吴朝阳,王远东. PI3K/Akt信号传导通路在肿瘤发生发展及治疗中的作用[J]. 现代肿瘤医学, 2021, 0(1): 177-180. DOI: 10.3969/j.issn.1672-4992.2021.01.040 |
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| 作者姓名： | 徐利本 吴朝阳 王远东 |
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| 作者单位： | 江苏大学附属人民医院放疗科,江苏 镇江 212000 |
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| 基金项目： | 镇江市社会发展指导性项目(编号:FZ2018034);江苏大学临床医学科技发展基金项目(编号:JLY20180001)。 |
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| 摘 要： | 在许多恶性肿瘤中PI3K/Akt信号通路的表达出现异常,影响多个靶标分子的功能,在肿瘤发生、发展过程中起着关键作用,与肿瘤细胞治疗抗拒、增殖凋亡、周期调控、侵袭转移及血管形成等过程密切相关。抑制该通路的方案已成为肿瘤治疗的研究热点,其中以通路中关键分子为靶点的靶向治疗有了长足发展。我们就PI3K/Akt信号通路的组成功能、调节及其对肿瘤形成和治疗的关系进行整理,希望为广大医务工作者提供参考。
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| 关 键 词： | PI3K/Akt 信号传导 肿瘤 综述 |
The role of PI3K/Akt signal pathway in the development and progression of tumor |
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| XU Liben,WU Chaoyang,WANG Yuandong. The role of PI3K/Akt signal pathway in the development and progression of tumor[J]. Journal of Modern Oncology, 2021, 0(1): 177-180. DOI: 10.3969/j.issn.1672-4992.2021.01.040 |
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| Authors: | XU Liben WU Chaoyang WANG Yuandong |
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| Affiliation: | Radiotherapy Department,the Affiliated People's Hospital of Jiangsu University,Jiangsu Zhenjiang 212000,China. |
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| Abstract: | PI3K/Akt signal transduction pathway is abnormally activated in many tumors,which affects the function of many target molecules.It plays a key role in the process of tumor formation and development,and participates in the process of cell proliferation,apoptosis,differentiation cycle regulation,invasion and migration,angiogenesis and so on.Inhibiting PI3K/Akt signaling pathway has become a research hotspot in cancer therapy.Tumor therapy strategies targeting key molecules of PI3K/Akt signaling pathway have developed rapidly.This article reviews the composition,function,regulation of PI3K/Akt pathway and its relationship with tumor formation,development and treatment. |
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| Keywords: | PI3K/Akt signal transduction cancer review |
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