|
|||||
|
|
| 高渗盐水对大鼠缺血再灌注损伤肾组织Na+-K+-ATP酶活性的影响 | |
| 引用本文： | 龚华渠,杨天德,周激.高渗盐水对大鼠缺血再灌注损伤肾组织Na+-K+-ATP酶活性的影响[J].中国误诊学杂志,2011,11(4):771-773. |
| 作者姓名： | 龚华渠 杨天德 周激 |
| 作者单位： | 1. 成都军区总医院麻醉科,四川,成都,610083 2. 第三军医大学新桥医院麻醉科,重庆,400037 3. 四川华美紫馨医学美容医院,四川,成都,610016 |
| 摘 要： | 目的 探讨高渗盐水对缺血再灌注损伤肾组织Na+-K+-ATP酶活性的影响.方法 56只SD大鼠随机分为假手术组(S组)、缺血再灌注组(IR组)和高渗盐水处理组(H组).肾缺血再灌注损伤模型的建立:左侧肾蒂夹闭45 min后松开,分别于再灌注4 h、6 h、12 h,测定左肾系数、血清肌酐(Cr)、左肾组织Na+-K+-ATP酶(Na+-K+-ATPase)活性和丙二醛(MDA)含量.结果 H组左肾系数、血清肌酐和丙二醛明显低于IR组,而左肾组织Na+-K+-ATP酶活性明显高于IR组.结论 高渗盐水预处理对实验SD大鼠缺血再灌注肾损伤有保护作用. |
| 关 键 词： | 再灌注损伤/代谢 盐水 高渗/药理学 Na(+)K(+)交换ATP酶/药物作用/代谢 |
Effects of hypertonic saline on the Na+-K+-ATPase activity of renal tissue after ischemic reperfusion injury in rats |
|
| GONG Hua-qu,YANG Tian-de,ZHOU Ji.Effects of hypertonic saline on the Na+-K+-ATPase activity of renal tissue after ischemic reperfusion injury in rats[J].Chinese Journal of Misdiagnostics,2011,11(4):771-773. | |
| Authors: | GONG Hua-qu YANG Tian-de ZHOU Ji |
| Institution: | GONG Hua-qu,YANG Tian-de,ZHOU Ji Department of anaesthesia,General Hospital of Chengdu Military District,Chengdu 610083,China |
| Abstract: | Objective To explore the effects of hypertonic saline on the Na+-K+-ATPase activity of renal tissue after ischemic-reperfusion injury in rats.Methods Fifty-six rats were divided randomly into the sham operative control group(S group),renal ischemia-reperfusion injury group(IR group) and hypertonic saline-treated group(H group).The model of renal ischemia reperfusion in rats was established by clamping the left renal pedicel in situ for 45 minutes before reperfusion of blood 4 hours,6 hours or 12 hours.The l... |
| Keywords: | Reperfusion Injury/metabolism Saline Solution Hypertonic/pharmacology Na( )-K( )-Exchanging ATPase/drug effects/metabolism |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |