中药胚胎毒性的研究现状和展望

具有胚胎毒性的中药古称“妊娠禁忌药”,是中药药性理论的重要内容之一。笔者通过对胚胎毒性中药的历史回顾和研究现状分析,阐述了中药胚胎毒性由妊娠禁忌到遗传毒性和生殖发育毒性的衍变发展过程以及中药有效成分在遗传和生殖发育毒性中的研究概况。同时,指出目前该研究领域存在的问题主要在于对胚胎毒性中药概念范畴的确定及其相关评价体系的建立等方面,认为解决的方法可以从严格控制有毒中药、正确炮制和合理配伍以及引申应用等多方面入手。此外,充分利用现代科学技术,也是胚胎毒性的中药标准化和规范化研究之必需。

Research actuality and expectation on embryo toxicity of traditional Chinese medicine

Traditional Chinese medicine with embryo toxicity has been named as abstinence medicine in cyesis in ancient times. Embryo toxicity is one of the key theories of traditional Chinese medicine. Based on history retrospective study and modern research, the paper expounded that the developing course of embryo toxicity of traditional Chinese medicine is from cyesis abstinence to inheritance toxicity and reproductive development toxicity, and overviewed the research of active components of traditional Chinese medicine in the domains of inheritance toxicity and reproductive development toxicity. Meanwhile, it pointed out that the main problem in the domain is about the definition of conception and category of traditional Chinese medicine with embryo toxicity and the foundation of relative assessment system. In the end, some suggestions were given to solve the problem including the control of poisonous traditional Chinese medicines, right processing, reasonable compatibility, extensional application, and utilizing modern science and technology.