Toxic effect of glutamate causes mitochondria damage in granule cells of dissociated cultures of rat cerebellum |
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| Authors: | N. K. Isaev R. E. Uzbekov D. B. Zorov E. V. Stel'mashuk I. V. Viktorov |
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| Affiliation: | (1) Institute of Brain Research, Russian Academy of Medical Sciences, Moscow;(2) Institute of Physicochemical Biology, M. V. Lomonosov State University, Moscow |
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| Abstract: | It is shown that treating rat cerebellum with glutamate in a neurocytotoxic concentration causes a drop of the mitochondrial membrane potential in granule cells and leads to ultrastructural alterations of mitochondria in these neurons. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N o 4, pp. 378–380, April, 1995. Presented by the late Member of the Russian Academy of Medical Sciences |
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| Keywords: | glutamate granule cells of cerebellum mitochondria |
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