| 麝香糖蛋白成分对大鼠中性白细胞花生四烯酸代谢酶的作用 |
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| 引用本文： | 王文杰,白金叶,程桂芳,朱秀媛. 麝香糖蛋白成分对大鼠中性白细胞花生四烯酸代谢酶的作用[J]. 中国中药杂志, 1997, 22(5): 301-303 |
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| 作者姓名： | 王文杰 白金叶 程桂芳 朱秀媛 |
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| 作者单位： | 中国医学科学院中国协和医科大学 |
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| 摘 要： | 采用体外温孵系统，观察麝香糖蛋白成分麝香－１对大鼠中性白细胞花生四烯酸代谢酶，包括磷脂酶Ａ２、５－脂氧酶和环氧酶活性的影响。结果表明：终浓度为１～１００μｇ／ｍｌ的麝香－１使ＡＡ释放量增加６．０％～２１．６％，使ＬＴＢ４生成量减少９％～８１％，使６－酮－ＰＧＦ１α生成量增加１８．２％～８５．４％。
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| 关 键 词： | 麝香 中性白细胞 磷脂酶A_2 5-脂氧酶 环氧酶 |
| 收稿时间： | 1996-04-23 |
The Effect of Glucoprotein Component of Musk on Arachidonic Acid Metabolizing Enzymes in Rat Polymorphonuclear Leukocytes |
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| Wang Wenjie,Bai Jinye,Cheng Guifang and Zhu Xiuyuan. The Effect of Glucoprotein Component of Musk on Arachidonic Acid Metabolizing Enzymes in Rat Polymorphonuclear Leukocytes[J]. China Journal of Chinese Materia Medica, 1997, 22(5): 301-303 |
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| Authors: | Wang Wenjie Bai Jinye Cheng Guifang Zhu Xiuyuan |
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| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing. |
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| Abstract: | To investigate the effects of musk-1, a glucoprotein component isolated from the water extract of musk, on arachidonic acid metabolizing enzymes, which include phospholipase A2(PLA2), 5-lipoxygenase (5-LO), and cyclooxygenase (COX), in rat polymorphonuclear leukocytes, an in vitro incubation system with rat polymorphonuclear leukocytes or homogenate supernatant of the same cells was used. In comparison with control, musk-1 at final concentrations of 1-100 micrograms/ml can increase AA release from PMNL by 6.0%-21.6%, decrease LTB4 biosynthesis in homogenate supernatant of the cells by 9%-81%, but increase 6-keto-PGF1 alpha production by 18.2%-85.4%. |
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| Keywords: | musk polymorphonuclear leukocyte phospholipaseA 2 5 lipoxygenase cyclooxygenase |
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