Genetic differences in immune reactions to radiation exposure in humans and experimental animals |
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| Authors: | Konenkov V I Trufakin V A |
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| Affiliation: | (1) Institute of Clinical Immunology; Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk |
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| Abstract: | Examination of populations living in regions of fallout radiation revealed changes in the distribution of HLA genes not only in irradiated individuals, but also in their children and grandchildren. Combined irradiation of inbred mice in comparable doses showed that H-2 genes determine immune reactions in animals and their offspring to radiation. Our results indicate that the immune system in mammals is immunogenetically regulated by low-dose radiation. |
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| Keywords: | radiation immune system major histocompatibility complex genes |
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