克林霉素磷酸酯治疗恶性肿瘤放疗后继发肺部厌氧菌感染

目的 :探讨克林霉素磷酸酯对恶性肿瘤放疗后继发肺部厌氧菌感染的治疗疗效及不良反应。材料和方法 :78例肺部接受过放射治疗的恶性肿瘤患者肺部继发厌氧菌感染随机分为克林霉素磷酸酯治疗组 (实验组 ) 4 1例和甲硝唑治疗组 (对照组 ) 37例。克林霉素磷酸酯 ,每次 30 0～ 6 0 0mg ,每日 2～ 3次 ,疗程 10～ 14d。甲硝唑 ,每次 5 0 0～ 75 0mg ,每日 2次或每 8h 1次 ,疗程 10～ 14d。结果 :(1)实验组痊愈率为 6 8 3% ,对照组为 45 9% ,P <0 .0 5 ,有效率分别为 80 5 % ,5 9 5 % ,P <0 .0 5 ;(2 )实验组致病菌清除率为 75 6 % ,对照组为 5 4 1% ,P <0 .0 5 ,;(3)不良反应发生率实验组为 2 2 % ,对照组为 45 9% ,P <0 .0 5。结论 :克林霉素磷酸酯对肺部放疗后继发肺部厌氧菌感染的治疗疗效好、副作用低

RESEARCH OF THE APPLICATION OF CLINDAMYCIN PHOSPHATE IN THE SUCCESSIVE LUNG INFECTION WITH ANAEROBIC BACTERIA AFTER RADIOTHERAPY

ObjectiveTo investigate the therapeutic outcome andeffect of Clindamycin Phosphate in the treatment of successive lung infection withanaerobic bacteria after radiotherapy.Materials and Methods78 patients with malignancycontracting successive lung infection with anaerobic bacteria followed by radiotherapywere randomly divided into 2 groups,41 people (Clindamycin Phosphate treatment group) and37 people (Miediling control group) Clindamycin phosphate,300～600 mg,Bid or Tid,10～14 days,Miediling 500～750 mg.Bid or once/8h,10～14days.Result(1)Both recovery and efficacious rate demonstratd a significant differencerespectively between treatment group and control group(68.3% vs 45.9%) (P<0.05),(80.5%vs 59.5%)(P<0.05);(2)There existed a significant difference in the lethal rate to thebacteria between treatment group and control group(75.6% vs 54.1%)(P<0.05);(3)Sideeffect incidence rate were 22% and 45.9% selarately (P<0.05).ConclusionThe applicationof clindamycin phosphate in the treatment of successive lung infection with anaerobicbacteria after radiotherapy displayed a better effect and smaller side effect.