急性重症胆管炎全身炎症反应综合征与多器官功能不全关系的研究

目的：研究急性重症胆管炎患者发生全身炎症反应综合征（ＳＩＲＳ） 和多器官功能不全综合征（ＭＯＤＳ） 的情况及两者之间的关系，从而为防治ＭＯＤＳ、降低急性重症胆管炎患者死亡率提供治疗对策。方法：选择１９８９ 年１ 月～１９９８ 年１２ 月间收治的１０４ 例急性重症胆管炎患者的临床资料，按照１９９１ 年８ 月ＡＣＣＰ和ＳＣＣＭ 会议的诊断标准，比较ＳＩＲＳ和ＭＯＤＳ的发病率。结果：所有急性重症胆管炎患者都发生ＳＩＲＳ，发病率为１００ ％ ，发生ＭＯＤＳ４１例，发病率为３９－４ ％ ，死亡２１ 例，均发生ＭＯＤＳ，死亡率为２０－２ ％ 。结论：所有急性重症胆管炎患者均发生ＳＩＲＳ，ＳＩＲＳ至ＭＯＤＳ是一个连续的发展过程，ＭＯＤＳ有很高的死亡率，早期诊断ＳＩＲＳ，并积极调控机体炎症反应，可能是改善急性重症胆管炎患者预后的关键

STUDY ON THE CORRELATION OF SYSTEMIC INFLAMMATORY RESPONSE SYNDROME WITH MULTIPLE ORGAN DYSFUNCTION SYNDROME OF ACUTE SEVERE CHOLECYSTiTIC PATIENT

Objective:To explore the correlation of systemic inflammatory response syndrome (SIRS) with multiple organ dysfunction syndrome (MODS) and to propose a therapeutic strategy for reducing the mortality of patients with acute severe cholecystitis (ACST).Methods:104 patients with ACST from Jan.1989 to Dec.1998 were selected.Compared with the morbidity of SIRS and MODS,according to the diagnosic standards of ACCP and SCCM 1991.Results:All of the patients with ACST suffered from SIRS and 41 of them from MODS.The morbidity is 100 percent and 39.4 percent respectively.21 of them died.All of them suffered from MODS.Conclusion:All of patients with ACST suffered from SIRS,the process from SIRS to MODS is successive.The outcome of ACST patients may be improved if SIRS is early diagnosed and the body inflammatory response is reglulated properly.