二十二碳六烯酸和二十碳四烯酸对早产儿脂肪酸状况和生长的影响

目的 :　探讨补充模拟母乳水平的二十二碳六烯酸 (DHA)和二十碳四烯酸 (AA)对早产儿体内脂肪酸状况和生长发育的影响。方法 :　选取体重 <2 1 0 0 g,胎龄 <37w的早产儿 32名 ,分为三组 :A组 ,母乳喂养组 ;B组 ,传统配方喂养组 ;C组 ,DHA和 AA补充组。C组配方补充至婴儿体重达 (2 .5± 0 .1 0 ) kg。出生后 1 mo± 7d、2 mo± 7d、3mo± 7d分别测量身长、体重、头围 ;出生时和体重达 (2 .5± 0 .1 0 ) kg时分别测血浆和红细胞中的 DHA和 AA的水平。结果 :　至 3个月时 ,B组的头围明显低于 A组及 C组 ,差异具有统计意义 (P<0 .0 5) ;三组早产儿刚出生时 ,红细胞和血浆中各种脂肪酸比例无显著差异 ;至体重 (2 .5± 0 .1 0 ) kg时 ,B组的 DHA和 AA明显低于A组和 C组 (P<0 .0 5)。相关分析显示 :头围与血浆中的 AA水平相关 (r=0 .466,P<0 .0 1 )。结论 :　给早产儿补充模拟母乳水平的 DHA和 AA,不仅能维持其正常的生长发育 ,而且可将早产儿血浆和红细胞中的 DHA和 AA提高至与母乳喂养早产儿相当的水平

EFFECT OF DOCOSAHEXAENOIC AND ARACHIDONIC ACID ON FATTY ACID STATUS AND GROWTH OF PREMATURE INFANTS

Objective: To study the influence of the dietary n 3 and n 6 long chain polyunsaturated fatty acids with 20 or 22 carbon atoms (LCPFA) intake on the LCPFA status, growth and development. WT5HZ]Methods: WT5BZ]32 preterm infants were divided into three groups which were fed respectively: A, breast milk (n=11); B, a conventional formula lacking LCP (n=10); C, docosahexaenoic acid (DHA) and arachidonic acid (AA) enriched formula (n=11). The length, weight and head circumference of preterm infants were measured at 1 mo±7 d, 2 mo±7 d, 3 mo±7 d. LCPFA status of plasma and RBC were analyzed at birth and at the weight of (2.5±0.10) kg when group C was stopped being fed enriched formula. The experiment period was three months. WT5HZ]Results: WT5BZ]At 3 mo±7 d, head circumference of group B was significantly lower than that of group A and group C (P<0.05); at the weight of 2.5 kg, DHA and AA in plasma and erythrocyte of group B were significantly lower than group A and group C (P<0.05). There was significantly positive correlation between AA levels of plasma and head circumference (r=0.466, P<0.01). WT5HZ]Conclusion:WT5BZ] Adding DHA and AA to formulas in amounts similar to those found in preterm breast milk can raise both DHA and AA status of preterm infants to the levels found in human milk fed preterm infants, and let these infants grow better.