Role of gamma interferon in Helicobacter pylori induction of inflammatory mediators during murine infection |
| |
Authors: | Obonyo Marygorret Guiney Donald G Harwood Julia Fierer Joshua Cole Sheri P |
| |
Affiliation: | Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA. |
| |
Abstract: | Gamma interferon (IFN-gamma) has been proposed to play an important role in Helicobacter-related gastritis. Using the IFN-gamma gene knockout (IFN-gamma(-/-)) mouse model and a murine gastric epithelial cell line, GSM06, we demonstrated that Helicobacter pylori maximally induced macrophage inflammatory protein-2 (MIP-2) and inducible nitric oxide synthase (iNOS) mRNA only in wild-type mice. MIP-2 and iNOS mRNA were also induced by H. pylori in GSM06 cells. Induction of cyclooxygenase 2 mRNA through IFN-gamma was demonstrated in GSM06 cells. These data indicate that IFN-gamma mediates the induction of MIP-2 and iNOS mRNA expression by H. pylori in mice. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|