| 硫酸依替米星注射液在5种输液中的稳定性考察 |
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| 引用本文： | 张全英,潘杰.硫酸依替米星注射液在5种输液中的稳定性考察[J].中国药学杂志,2003,38(4):279-281. |
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| 作者姓名： | 张全英 潘杰 |
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| 作者单位： | 苏州大学第二附属医院药剂科,江苏,苏州,215004 |
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| 摘 要： | 目的研究硫酸依替米星注射液(悉能)与5种常用输液配伍的稳定性。方法采用柱前OPA衍生化HPLC，考察悉能与5种输液按临床应用配伍，于25℃和35℃条件下，6ｈ内pH，外观，含量变化情况。结果在25℃条件下，悉能与5种输液配伍后6ｈ内基本稳定，在35℃条件下配伍后4ｈ内基本稳定，4ｈ后含量下降明显。结论悉能与5种输液可以配伍使用，但在35℃时应于2～4ｈ内用完。
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| 关 键 词： | 依替米星 输液 稳定性 高效液相色谱法 |
| 文章编号： | 1001-2494(2003)04-0279-03 |
| 收稿时间： | 2002-02-26; |
| 修稿时间： | 2002年2月26日 |
Study on the stability of etimicin in infusion solutions by HPLC |
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| ZHANG Quan-ying,PAN Jie.Study on the stability of etimicin in infusion solutions by HPLC[J].Chinese Pharmaceutical Journal,2003,38(4):279-281. |
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| Authors: | ZHANG Quan-ying PAN Jie |
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| Institution: | Department of Pharmacy,The Second Affiliated Hospital of Suzhou University,Suzhou 215004,China |
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| Abstract: | OBJECTIVE To observe the stability of Etimicin sulfate injection in infusion solutions.METHOD S The method utilized pre column derivation with OPA by HPLC.The color and clarity were assessed,and pH was measured at 25℃ and 35℃for 6 h.RESULTS At 25℃,all solution containing etimicin retained more than 90% of their initial levels,pH and appearance had no significant change.There was significant declination of their levels at 35℃for 4 h.CONCLUSION Etimicin in infusion solutions should be used in 2～4 h at 35℃. |
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| Keywords: | etimicin infusion stability HPLC deter mination |
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