|
|||||
|
|
Quinic acid esters from Pluchea indica with collagenase, MMP-2 and MMP-9 inhibitory activities |
|
| Authors: | Ohtsuki Takashi Yokosawa Emiko Koyano Takashi Preeprame Srisomporn Kowithayakorn Thaworn Sakai Shinobu Toida Toshihiko Ishibashi Masami |
| Institution: | Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. |
| Abstract: | Investigation of collagenase inhibitory natural components afforded two quinic acid esters (1 and 2) and quercetin (3) from the leaves of Pluchea indica (Compositae). Of these, compounds 1 and 2 exhibited collagenase inhibitory activity (IC(50)) at a concentration of less than 10 microm, and 1 showed matrix metalloproteinase (MMP)-2 and -9 inhibitory activity (IC(50)) at 2.5 and 6.4 microm, respectively. |
| Keywords: | quinic acid ester collagenase matrix metalloproteinase Pluchea indica |
| 本文献已被 PubMed 等数据库收录！ | |