针刺分离联合结膜下注射5-氟尿嘧啶治疗小梁切除术后功能不良滤过泡

目的：：探究针刺分离联合结膜下注射5-氟尿嘧啶治疗小梁切除术后功能不良滤过泡的临床效果。方法：选取行小梁切除术后1~4 wk来院复诊的青光眼患者26例30眼,对功能不良的滤过泡进行针刺分离联合膜下注射5-氟尿嘧啶进行治疗。观察滤过泡形态、眼压和并发症,随访3 mo。结果：针刺分离后滤过泡形态有24眼表现为功能性滤过泡。针刺分离前患者眼压为26.4±2.8mmHg,分离后眼压为14.1±1.1mmHg,两者差异有统计学意义(P<0.05)。治疗后治愈率70%(21眼),有效率17%(5眼),总有效率87%。常见并发症包括结膜下出血、角膜上皮点状剥脱和前房积血。结论：针刺分离联合结膜下注射5-氟尿嘧啶对小梁切除术后功能不良滤过泡有着良好效果,值得在临床治疗中推广应用。

Needle revision with subconjunctival injection of 5-fluorouracil for failed filtering blebs after trabeculectomy

AlM:To explore the clinical effect of needle revision combined with 5-fluorouracil (5-FU) for the disfunctional blebs after trabeculectomy. METHODS: Needle revision combined with subconjunctival injection of 5 - FU treatment was conducted on 30 eyes in 26 patients with disfunctional blebs at clinic visits at 1 ~ 4wk immediately after trabeculectomy. The morphology, intraocular pressure ( lOP ) and complications of the filtering blebs were observed, and all the patients were followed up for 3mo.RESULTS:The morphology of filtering blebs was normal in 24 eyes after needle revision treatment. The pre -treatment lOP was 26. 4 ± 2. 8mmHg, and the post -treatment lOP was 14. 1 ± 1. 1mmHg, and the difference was statistically significant (P<0. 05). The cure rate was 70% (21 eyes), effective rate was 17% (5 eyes), and the total was 87%. Common complications included subconjunctival hemorrhage, corneal epithelium dot stripped and hyphema.CONCLUSlON:The combination of needle revision and 5-FU has a good effect for failed filtering blebs after trabeculectomy. lt is worthy promotion in clinical treatment.