| 调节血栓中组织因子表达的中药有效成分研究进展 |
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| 引用本文： | 庞国凤,郝二伟,周凯,邓家刚. 调节血栓中组织因子表达的中药有效成分研究进展[J]. 中草药, 2016, 47(6): 1043-1048 |
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| 作者姓名： | 庞国凤 郝二伟 周凯 邓家刚 |
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| 作者单位： | 广西中医药大学, 广西 南宁 530001;广西中医药大学, 广西 南宁 530001;广西中药药效筛选重点实验室, 广西 南宁 530001;广西中医药大学, 广西 南宁 530001;广西中医药大学, 广西 南宁 530001;广西中药药效筛选重点实验室, 广西 南宁 530001 |
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| 基金项目： | 广西省自然科学基金资助项目(2013GXNSFBA019145);广西科技基础条件平台建设项目(10-046-04,13-051-06);广西中医药大学课题(P2012019) |
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| 摘 要： | 组织因子(tissue factor,TF)亦称为组织凝血活酶,是生理性止、凝血过程及多种病理性血栓形成的启动因子,在动脉粥样硬化、系统性炎症、心绞痛、弥散性血管内凝血、肿瘤的血管发生与转移等多种疾病的形成中发挥重要作用。寻找以TF为靶点的抗凝、抗血栓药物具有重要的理论和现实意义,概述了近年来对血栓形成中TF表达具有调节作用的中药有效成分的研究进展。
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| 关 键 词： | 组织因子 抗凝 抗血栓 中药有效成分 血栓形成 |
| 收稿时间： | 2015-10-22 |
Research progress in active components in Chinese materia medica with modulating effects on expression of tissue factor in thrombosis |
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| PANG Guo-feng,HAO Er-wei,ZHOU Kai and DENG Jia-gang. Research progress in active components in Chinese materia medica with modulating effects on expression of tissue factor in thrombosis[J]. Chinese Traditional and Herbal Drugs, 2016, 47(6): 1043-1048 |
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| Authors: | PANG Guo-feng HAO Er-wei ZHOU Kai DENG Jia-gang |
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| Affiliation: | University of Traditional Chinese Medicine in Guangxi, Nanning 530001, China;University of Traditional Chinese Medicine in Guangxi, Nanning 530001, China;Guangxi Key Laboratory for of Screening Traditional Chinese Medicine Efficacy, Nanning 530001, China;University of Traditional Chinese Medicine in Guangxi, Nanning 530001, China;University of Traditional Chinese Medicine in Guangxi, Nanning 530001, China;Guangxi Key Laboratory for of Screening Traditional Chinese Medicine Efficacy, Nanning 530001, China |
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| Abstract: | Tissue factor (TF), also called tissue thromboplastin, is the principal initiator of physiological blood coagulation and hemostasis and pathological thrombosis, and plays an important role in the formation of various diseases in atherosclerosis, systemic inflammation, angor pectoris, disseminated intravascular coagulation, and tumor angiogenesis and metastasis. Looking for the targets to TF anticoagulant, antithrombotic drug has important theoretical and realistic significance. This summary outlines the research progress of the active components in Chinese materia medica with modulating effects on expression of tissue factor in thrombosis in recent years. |
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| Keywords: | tissue factor anti-freezing anti-thrombosis active component of Chinese materia medica thrombosis |
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