2HRZE/4HR与3HESO/9HEO化疗方案治疗肺结核合并慢性乙型肝炎患者的疗效及对肝功能的影响对比

目的:探讨在肺结核合并慢性乙肝患者治疗中分别应用2HRZE/4HR与3HESO/9HEO化疗方案的临床效果及肝功能影响。方法:从我院2012年3月至2014年3月收治的肺结核合并慢性乙肝患者中选取84例为研究对象,经随机数字表法分为A组42例,B组42例。A组患者给予3HESO/9HEO化疗方案治疗,疗程12个月;B组患者给予2HRZE/4HR化疗方案治疗,疗程6个月,观察两组患者治疗效果,症状改善情况,肝功能变化及不良反应发生情况。结果:A组治疗总有效率为95.24%,明显高于B组的80.95%(P<0.05);A组肺结核症状改善情况明显优于B组(P<0.05);两组患者治疗前肝功能指标无明显差异(P>0.05),A组治疗后各指标情况明显优于B组(P<0.05);A组不良反应发生率为6.98%,低于B组的19.05%(P<0.05)。结论:对于肺结核合并慢性乙肝患者,应用3HESO/9HEO化疗方案治疗,效果更为确切,且对肝功能损伤较小,安全性更高,值得推广。

Efficacy and impact on liver function of 2HRZE/4HR and 3HESO/9HEO chemotherapy regimen treating pulmonary tuberculosis patients with chro-nic hepatitis B

Objective:To investigate the clinical efficacy of 2HRZE /4HR and 3HESO /9HEO chemotherapy regimen treating pulmonary tuberculosis patients with chronic hepatitis B,and their impact on liver function.Methods:84 cases of pulmonary tuberculo-sis patients with chronic hepatitis B admitted in our hospital from March 2012 to March 2014 were selected and divided into two groups (A and B)by random digital table method,42 in each.Group A were treated with 3HESO /9HEO for 12 months.Group B were treated with 2HRZE /4HR for 6 months.The treatment effect,improvement of symptoms,changes of liver function and adverse reactions were observed.Results:The total effective rate of Group A was 95.24%,significantly higher than 80.95% of Group B.Symptoms of pulmo-nary tuberculosis of Group A improved more obviously than Group B.There was no significant difference in liver function index between the two groups before treatment (P >0.05),and the index of the Group A was significantly better than that in the Group B after treat-ment (P <0.05).The incidence of adverse reactions in Group A was 6.98% significantly lower than 19.05% in Group B (P <0. 05).Conclusion:3HESO /9HEO chemotherapy regimen treating pulmonary tuberculosis patients with chronic hepatitis B has more pre-cise effect,less damage to the liver function,higher safety and is worthy of promotion.