Pravastatin has no direct effect on transmembrane cationic transport systems in human erythrocytes and platelets

In vitro incubation of human erythrocytes and platelets with the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor pravastatin in the concentration range 1 nM to 10μM did not affect the activity of the Na⁺−K⁺-pump, Na⁺−K⁺-cotransport or Na⁺−Li⁺-countertransport, or the ground membrane leak for Na⁺ and K⁺. The data indicate that pravastatin has no direct effect on transmembrane cationic transport systems in red blood cells or platelets.