An overnight switch to ropinirole therapy in patients with Parkinson's disease |
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| Authors: | M Canesi A Antonini C B Mariani S Tesei A L Zecchinelli M Barichella G Pezzoli |
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| Institution: | Parkinson Institute Milan, Istituti Clinici di Perfezionamento, Milan, Italy. |
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| Abstract: | Patients with Parkinson's disease (n = 68) switched from pergolide or bromocriptine to ropinirole overnight (dose equivalence ratios 1:6 and 10:6, respectively). The activities of daily living score for the Unified Parkinson's Disease Rating Scale (UPDRS) was significantly improved 4 weeks after the bromocriptine-ropinirole switch. All other UPDRS scores, including that for the side-effect component, were not significantly different after either switch. Overnight switching may be a safe therapeutic approach that may reduce hospitalisation and related socio-economic costs. |
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