罗库溴铵TCI系统在不同性别患者应用评价

目的评估对罗库溴铵靶控输注（TCI）系统用于不同性别患者的差异。方法选择ASAⅠ～Ⅱ级,择期全麻手术患者60例,分为男性组（M组）和女性组（W组）,各30例。诱导插管时罗库溴铵靶浓度设为6μg/ml,术中维持靶浓度为0.8μg/ml,术中根据手术需要以0.2μg/ml增减调整靶浓度,维持10%≥T1/TC〉0。观察各组插管起效时间、术后肌松恢复,记录插管时（T1）、TCI开始后20min（T2）、40min（T3）,手术结束（T4）时的罗库溴铵靶浓度和血药浓度。结果 W组的起效时间显著短于M组（P〈0.05）,W组的肌松恢复时间和恢复指数显著长于M组（P〈0.05）,TCI开始后20min（T2）、40min（T3）,手术结束（T4）时的罗库溴铵靶浓度和血药浓度。在W组显著低于M组（P〈0.05）。结论罗库溴铵的作用存在显著性别差异,但其机制尚待进一步研究。

Evaluation of target-controlled infusion of rocuronium in different sex patients

Objective To evaluate the performance of target-controlled infusion system for rocuronium in different sex patients.Methods 60 patients（ASA Ⅰ~Ⅱ）scheduled for selective surgical procedure under general anaesthesia were studied.The patients were divided into two groups equally,Man group（Group M） and Woman group（Group W）.The target effective site concentration of rocuronium for intubation was 6 in each group;and the target effective site concentration during operation was 0.8 μg/ml,and was increased or decreased by 0.2 μg/ml to maintain 10%≥T1/TC0.The effective time,recover time,target rocuronium concentrations and blood rocuronium concentrations were recorded in intubation（T1）,20 min after TCI（T2）,40 min after TCI（T3） and end of operation（T4）.Results The effective time of group W was significant shorter than group M（P0.05）.The recover time and recover index of group W were significant longer than group M（P0.05）.Target rocuronium concentrations and Blood rocuronium concentrations of group M were significant higher than group W in T1,T2,T3 and T4（P0.05）.Conclusion The influence of patients sex on TCI of rocuronium is significant,but the mechanism need to study further.