大肠癌中CXCR4、MMP—2的表达与血管新生及肿瘤转移的临床意义 |
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引用本文: | 尹林林,李静,王静,张刚峰.大肠癌中CXCR4、MMP—2的表达与血管新生及肿瘤转移的临床意义[J].陕西肿瘤医学,2008(12):2130-2133. |
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作者姓名: | 尹林林 李静 王静 张刚峰 |
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作者单位: | 山东省济南市第四人民医院肿瘤科,山东济南250031 |
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摘 要: | 目的:观察趋化性细胞因子受体CXCR4、基质金属蛋白酶MMP-2在大肠癌中的表达及其与血管新生的关系及其临床意义。方法:用免疫组化法检测56例大肠癌、10例癌旁组织中CXCR4、MMP-2的表达,用血管VIII因子标记血管内皮细胞计数微血管密度,分析CXCR4和MMP-2表达与MVD及临床病理特征的关系。结果:56例大肠癌组织CXCR4阳性率64.3%,10例癌旁组织中阳性率20%,差异有显著性意义。56例大肠癌组织MMP-2阳性率78.5,10例癌旁组织阳性率30%,差异有显著性意义。CXCR4和MMP-2的表达与大肠癌患者的临床分期、淋巴结转移和MVD密切相关。结论:CXCR4和MMP-2在大肠癌中的表达明显升高,可能与大肠癌血管生成和肿瘤转移有关。
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关 键 词: | 趋化因子受体 大肠癌 基质金属蛋白酶 微血管密度 转移 |
Expression of CXCR4 and MMP -2. in colorectal cancer and their relationship with mi- crovessel density and tumor metastasis |
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Institution: | YIN Lin - lin, LI Jing, WANG Jing, ZHANG Gang - feng( The Fourth People's Hospital of Jinan, Jinan 250031, China.) |
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Abstract: | Objective: To investigate the expression of chemokine receptor CXCR4 and of matrix metalloproteinase MMP -2 and analyse the relationship among the expression of CXCR4, MMP -2 and microvessel density, the clinic pathological diameters in colorectal cancer. Methods: The expression of CXCR4 and MMP - 2 in 56 colorectal canc- ers and 10 normal colorectal specimens was evaluated by immunohistochemistry. VIII immunostaining was used to measure the microvessel density. The correlation among the the expression of chemokine receptor CXCR4, MMP - 2 and MVD, the clinical pathological diameters was evaluated. Results: CXCR4 - positive expression was 64.3% ( 36/ 56) in colorectal cancers,20% (2/10) in normal colorectal tissues, expression was 78.5% (44/56) in colorectal cancers,30% (3/10) in normal colorectal tissues. However,the expression of CXCR4 and MMP -2 were relevant to clinical stage, lymph node metastasis and MVD. Conclusion: The expression of CXCR4 and MMP - 2 was distinctly higher in colorectal cancers. CXCR4 and MMP - 2 may promote the angiogenesis and the metastasis in colorectal cancer. |
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Keywords: | chemokine receptor colorectal cancer matrix metalloproteinase microvessel density metastasis |
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