OLF与LFP方案治疗晚期大肠癌的临床对比观察

目的：研究奥沙利铂与氟尿嘧啶、亚叶酸钙联合运用，治疗晚期大肠癌的疗效和毒副反应。方法：治疗组（A=35例）采用奥沙利铂100rag／m2静滴2小时，第1天；亚叶酸钙200rag／m2；静滴2小时，第1—5天；氟尿嘧啶300mg／m2静滴24小时，第1—5天（于亚叶酸钙静滴完后用）。对照组（B=33例）采用顺铂20mg／m2静滴，第1—5天；亚叶酸钙200mg／m2静滴2小时，第1—5天；氟尿嘧啶500mg／m2静滴24小时，第1—5天；21天或28天为1周期。结果：总有效率A组为45．7％，B组为33．3％，两组1，3年无进展生存率分别为71．4％和48．5％，51．4％和27．3％；均有显著性差异（P〈0．05）；毒副反应以骨髓抑制、恶心呕吐、感觉性神经毒性为主，多为Ⅰ-Ⅱ度。结论：奥沙利铂与氟尿嘧啶、亚叶酸钙联合运用治疗晚期大肠癌疗效肯定，毒副反应轻病人能耐受。

Oxaliplatin combined fluorouracil and calium folinate in the treatment of 35 cases with advanced colorectal cancer

Objective：To study the response and toxicity of the regimen of oxaliplatin combined with fluorouracil and calcium folinate in the treatment of advanced colorectal cancer. Methods： Thirty five patients （A） with advanced colorectal cancer received chemotherapy：oxaliplatin 100mg/m2 iv 2 hours on dayl, calcium folinate 200mg/m2 iv 2 hours days 1 to 5, followed by fluorouracil 300 mg/m2 iv 24 hours on day 1 to 5, and the other 34 cases （B） were treated with cisplatin 20mg/m2 iv 2 hours on day 1 to 5 ,calcium folinate 200mg/m2 iv 2 hours on day 1 to 5 ,followed by fluorouracil 500 mg/m2 iv 24 hours on day 1 to 5, three or four weeks as on cycle. Results ： The tolal response rate of group A was 45.7% and group B was 33.3 %, thel - year and 3 - year survival rates of the two gourps were 71.4% and 48.5% ,51.4% and 27.3%, （P 〈0.05） ; the main toxicity was bone marrow suppression,nausea emesis and neuro - sensory toxicity, but most were grade Ⅰ and Ⅱ. Conduslon： Regimen of oxaliplatin combined fluorouracil and calcium folinate is effective and tolerable in advanced colorectal cancer therapy.