Partial Penectomy for Patients With Squamous Cell Carcinoma of the Penis: The Memorial Sloan-Kettering Experience |
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Authors: | Ruslan Korets MD Theresa M Koppie MD Mark E Snyder BA Paul Russo MD |
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Institution: | (1) Department of Surgery, Urology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA |
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Abstract: | Background To present our institution’s experience with squamous cell carcinoma (SCC) of the penis, with analysis of oncologic efficacy
and survival.
Methods Between 1989 and 2005, we identified 32 consecutive patients (median age, 61 years) with SCC of the penis managed with partial
penectomy. Clinicopathologic variables were examined, and overall and disease-specific survival were determined.
Results Pathologic stage of the primary tumor was pTis in 1 patient (3%), pT1 in 11 (34%), pT2 in 16 (50%), and pT3 in 4 (13%). Pathologic
grade was well differentiated in 9 patients (28%), moderately differentiated in 20 (63%), and poorly differentiated in 2 (6%).
Twenty-five patients (78%) underwent inguinal lymph node dissection, with 15 (60%) demonstrating nodal metastases. Twenty-two
patients (69%) underwent pelvic lymph node dissection; 21 were negative for pelvic nodal metastases, and 1 had grossly positive
nodes. One patient developed local recurrence. After a mean follow-up of 34 months, overall survival was 56%. Numbers of patients
alive and disease-free were 9 and 11 in the low-stage and advanced-stage groups, and 8 and 12 in the well and moderately differentiated
groups, respectively. Both patients with poorly differentiated disease died of disease within 12 months from presentation.
Conclusions Partial penectomy for SCC of the penis provides excellent local control, with low recurrence rate, and acceptable maintenance
of urinary and sexual function. Outcomes are generally poor, however, for patients with regional metastases, even in moderately
differentiated disease. Future studies are needed to identify a reliable method of predicting regional metastases. |
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Keywords: | Penile neoplasms Carcinoma squamous cell Urologic surgical procedures male Lymph node excision |
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