Influenza vaccination in elderly residents in nursing homes: Immune response to trivalent and monovalent inactivated influenza virus vaccine in the season 1986–87 |
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| Authors: | G. Mancini G. Arangio-Ruiz B. Bianchi L. Diana T. Macchia I. Donatelli M. R. Castrucci L. Campitelli A. Ruggieri |
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| Affiliation: | (1) Dipartimento di Virologia, Istituto Superiore Sanitá, Viale Regina Elena 299, 00161 Roma, Italy;(2) Unitá Sanitaria Locale 2, Largo Matteotti 17, 54100 Massa Carrara, Italy;(3) Dipartimento di Biochimica Clinica, Istituto Superiore Sanitá, Viale Regina Elena 299, 00161 Roma, Italy |
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| Abstract: | Immune responses to trivalent inactivated whole virus and monovalent subunit influenza vaccines, used in the season 1986–87, were analyzed in elderly residents in nursing homes. Higher levels of induced antibody were found in the group receiving two doses of trivalent vaccine. This suggests that high risk aged patients should receive a booster dose of vaccine annually. The antibody response to administration of supplemental vaccination, using monovalent subunit preparation, did not reach the high level of antibodies found following trivalent influenza vaccine. |
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| Keywords: | Influenza Vaccination Elderly Immunity |
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