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Human tear fluid modulates the Pseudomonas aeruginosa transcriptome to alter antibiotic susceptibility
Affiliation:1. School of Optometry, University of California, Berkeley, CA, USA;2. College of Pharmacy, Touro University California, Vallejo, CA, USA;3. Graduate Groups in Vision Science, Microbiology, and Infectious Diseases & Immunity, University of California, Berkeley, CA, USA;1. Center for Translational Ocular Immunology, USA;2. Cornea Service, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine Boston, MA, USA;3. Department of Ophthalmology, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA;1. Department of Environmental Health Sciences, Yale School of Public Health, Yale University, 60 College Street, New Haven, CT, USA;2. Department of Cellular & Molecular Physiology, Yale School of Medicine, Yale University, New Haven, CT, USA;3. Bioinformatics Support Program, Cushing/Whitney Medical Library, Yale School of Medicine, New Haven, CT, USA;4. Department of Medicine, Yale University School of Medicine, New Haven, CT, USA;5. Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA;6. Department of Ophthalmology & Visual Science, Yale School of Medicine, New Haven, CT, USA;7. Department of Pathology, Anschutz School of Medicine, University of Colorado, Aurora, CO, USA;8. Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA;9. Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA;1. Brookline, MA, USA;2. TFOS, Boston, MA, USA;3. Department of Ophthalmology, Antioquia Ophthalmology Clinic-Clofan, Medellin, Antioquia, Colombia;4. Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas – UNICAMP, São Paulo, Brazil;5. Ocular Surface Center and Department of Ophthalmology, Sacco Hospital, Milan University, Milan, Italy;6. Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand;7. Ophthalmology Department, Lebanese University, Beirut, Lebanon;8. Earlam and Christopher Optometrists and Contact Lens Specialists, Taunton, UK;9. Department of Ophthalmology and Visual Sciences, Federal University of São Paulo/Paulista School of Medicine, São Paulo, Brazil;10. University of Cape Town, Cape Town, South Africa;11. Sankara Nethralya, Chennai, Tamil Nadu, India;12. Cornea and Refractive Surgery, Beirut Eye and ENT Specialist Hospital, Ophthalmology Department, Lebanese University, Beirut, Lebanon, and Mediclinic Dubai Mall, Dubai, United Arab Emirates;13. Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan;14. Department of Optometry and Visual Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana;15. Cabinet Ophthalmologie, Alger Centre, Algiers, Algeria;p. Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA;q. Ophthalmology Department, Saint Joseph University, Beirut, Lebanon;r. Institute of Ophthalmology, Conde de Valenciana, National Autonomous University of Mexico, UNAM, Mexico City, Mexico;s. Department of Optometry, School of Health Sciences at the College of Health Sciences, Makerere University, Kampala, Uganda;t. University of Alexandria, Alexandria, Egypt;u. Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan;v. School of Optometry and Vision Science, UNSW Sydney, Sydney, Australia;w. Section of Academic Ophthalmology, King''s College London, London, UK, and Departments of Ophthalmology and Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands;x. Department of Specialized, Experimental, and Diagnostic Medicine, University of Bologna, Bologna, Italy
Abstract:
Keywords:Tear fluid  RNA-Sequencing  Antimicrobial susceptibility  Polymyxin B  Tear-like fluid
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