CircadiOmic medicine and aging |
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| Affiliation: | 1. Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA, 01003, USA;2. Key Laboratory of Agrometeorology of Jiangsu Province, Department of Ecology, School of Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing, 210044, China;3. Saint Francis Hospital and Medical Center, Hartford, CT, USA;4. Sri Guru Ram Das (SGRD), University of Health Sciences, Amritsar, India;5. 7 West Melrose Avenue, Baltimore, MD, 21210, USA;6. Department of Biomedical and Biotechnological Sciences, School of Medicine University of Catania, Via Santa Sofia 97, Catania, 95123, Italy;1. School of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Belfast, United Kingdom;2. Northern Ireland Centre for Stratified Medicine, Biomedical Sciences Research Institute, University of Ulster, C-TRIC Building, Altnagelvin Area Hospital, Londonderry, United Kingdom;3. Meadowlands Ambulatory Care Centre, Belfast Health and Social Care Trust, Belfast, United Kingdom |
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| Abstract: | The earth displays daily, seasonal and annual environmental cycles that have led to evolutionarily adapted ultradian, circadian and infradian rhythmicities in the entire biosphere. All biological organisms must adapt to these cycles that synchronize the function of their circadiome. The objective of this review is to discuss the latest knowledge regarding the role of circadiomics in health and aging. The biological timekeepers are responsive to the environmental cues at microsecond to seasonal time-scales and act with precision of a clock machinery. The robustness of these rhythms is essential to normal daily function of cells, tissues and organs. Mis-alignment of circadian rhythms makes the individual prone to aging, sleep disorders, cancer, diabetes, and neuro-degenerative diseases. Circadian and CircadiOmic medicine are emerging fields that leverage our in-depth understanding of health issues, that arise as a result of disturbances in circadian rhythms, towards establishing better therapeutic approaches in personalized medicine and for geroprotection. |
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| Keywords: | Aging Aging Clock Epigenetic Modifiers Circadian |
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