Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions |
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| Institution: | 1. Center for Translational Ocular Immunology, USA;2. Cornea Service, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine Boston, MA, USA;3. Department of Ophthalmology, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA;1. Department of Environmental Health Sciences, Yale School of Public Health, Yale University, 60 College Street, New Haven, CT, USA;2. Department of Cellular & Molecular Physiology, Yale School of Medicine, Yale University, New Haven, CT, USA;3. Bioinformatics Support Program, Cushing/Whitney Medical Library, Yale School of Medicine, New Haven, CT, USA;4. Department of Medicine, Yale University School of Medicine, New Haven, CT, USA;5. Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA;6. Department of Ophthalmology & Visual Science, Yale School of Medicine, New Haven, CT, USA;7. Department of Pathology, Anschutz School of Medicine, University of Colorado, Aurora, CO, USA;8. Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA;9. Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA;1. Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan;2. Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu, Chiba, 279-0021, Japan;3. Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan;4. Laboratory of Cell Biotechnology, Biotechnology Research Center, The University of Tokyo, Tokyo, 113-8657, Japan;5. Department of Science of Allergy and Inflammation, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan;6. Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan;7. Department of Immunological Diagnosis, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan;1. Department of Ophthalmology, Boston Children''s Hospital, Harvard Medical School, Boston, MA, USA;2. Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA;3. Department of Ophthalmology, Benha University Hospitals, Benha University, Benha, Egypt;4. Department of Ophthalmology, Kasr Al-Ainy Hospitals, Cairo University, Cairo, Egypt;5. Department of Ophthalmology, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, IL, USA;6. Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA;7. Department of Ophthalmology, Research Institute of Ophthalmology, Cairo University, Cairo, Egypt;1. School of Optometry, University of California, Berkeley, CA, USA;2. College of Pharmacy, Touro University California, Vallejo, CA, USA;3. Graduate Groups in Vision Science, Microbiology, and Infectious Diseases & Immunity, University of California, Berkeley, CA, USA;1. Sussex Eye Hospital, Brighton, UK;2. Brighton and Sussex Medical School, Brighton, UK;3. Bristol Eye Hospital, Bristol, UK;4. Eye Research Centre, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran;5. Tongdean Eye Clinic, Brighton, UK;1. Laboratory of Experimental Ophthalmology, Department of Ophthalmology, Pius-Hospital, Carl von Ossietzky University Oldenburg, Germany;2. Laboratory of Experimental Ophthalmology, Department of Ophthalmology, University Hospital Duesseldorf, Heinrich-Heine-University, Germany;3. Department of Ophthalmology, Asklepios Hospital Nord-Heidberg, Hamburg, Germany |
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| Abstract: | PurposeDescribe the utility of anterior segment optical coherence tomography angiography (AS-OCTA) to assess ocular surface lesions.MethodsRetrospective, case-control study of 10 eyes of 9 patients with malignant lesions and 23 eyes of 22 patients with benign lesions. Lesions included 13 epithelial, 10 pigmented and 10 lymphoid lesions. Graders performed an average of 3 depth and diameter measurements of peri-lesional vessels entering each lesion on AS-OCTA. Statistical models to assess differences between groups accounted for bilateral eye inclusion and lesion thickness (on AS-OCT). Receiver operating characteristic (ROC) curve and area under the curve (AUC) were performed for each parameter.ResultsIn the benign and malignant groups, age was 49.5 ± 22.4 and 64.3 ± 10.6 years (p = 0.145) with 45% males and 55% males (p = 0.458), in their respective groups. AS-OCTA showed greater peri-lesional vessel depth and diameter in malignant lesions (315.2 ± 73.0 μm, p < 0.001 and 76.4 ± 18.2 μm, p < 0.001; respectively) compared to benign lesions (199.4 ± 34.1 μm and 44.0 ± 9.4 μm, respectively). Malignant lesions showed deep and dilated peri-lesional vessels, which may represent feeder vessels. Vessel depth showed AUC = 0.980, 90.9% sensitivity and 100.0% specificity with a 236.5 μm cutoff. Vessel diameter showed AUC = 0.960, 100.0% sensitivity and 88.9% specificity with a 53.9 μm cutoff.ConclusionAS-OCTA shows greater peri-lesional vessel depth and diameter of malignant lesions compared to benign lesions. This imaging modality provides novel and non-invasive functional vascular parameters that can potentially aid the assessment of ocular surface lesions. |
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| Keywords: | Conjunctival tumors Optical coherence tomography angiography AS-OCTA Feeder vessel OCTA Ocular surface neoplasia |
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