| 磷脂酶A_2活性异常升高可能是腰椎间盘突出症疼痛重要病因 |
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| 引用本文： | 杨维琦,李世和,王宏邦,曾才铭,马如龙,李家林. 磷脂酶A_2活性异常升高可能是腰椎间盘突出症疼痛重要病因[J]. 颈腰痛杂志, 2000, 0(3) |
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| 作者姓名： | 杨维琦 李世和 王宏邦 曾才铭 马如龙 李家林 |
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| 作者单位： | 昆明医学院第一附属医院骨科(杨维琦，李世和，王宏邦，曾才铭，马如龙)，昆明医学院生化教研室!云南昆明650021(李家林) |
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| 摘 要： | 目的 :探讨腰椎间盘突出症疼痛的可能病因。方法 :用微量酸滴定法测定椎间盘、黄韧带和硬膜外脂肪中 PL A2 活性。结果 :腰椎间盘突出症患者椎间盘、黄韧带和硬膜外脂肪中 PL A2 活性升高均有显著性意义 (三者 P均 <0 .0 0 1)且三者间均有相关性 (r椎 ,黄 =0 .6 86 3,P=0 .0 0 1;r=椎 ,硬 =0 .7388,P<0 .0 0 1;r黄 ,硬 =0 .6 113,P<0 .0 0 5 )。结论 :椎间盘退变的病理变化不仅发生在椎间盘本身 ,还涉及到同一节段的黄韧带和硬膜外脂肪 ,可能是它们中活性异常升高的 PL A2 共同作用神经根而致痛的。
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| 关 键 词： | 腰椎间盘突出症 磷脂酶A2 |
High level of phospholipase A_2(PLA_2) activity an induce in radicular pain of lumbar disc herniation |
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| YANG Wei-qi,LI Shi-he,WANG Hong-bang,et al.. High level of phospholipase A_2(PLA_2) activity an induce in radicular pain of lumbar disc herniation[J]. The Journal of Cervicodynia and Lumbodynia, 2000, 0(3) |
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| Authors: | YANG Wei-qi LI Shi-he WANG Hong-bang et al. |
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| Abstract: | Objective: To elucidate the pathomechanism of radicular pain of lumbar disc herniation.Method: The PLA 2 activity in disc ,ligamentum flavum and epidural fat removed at surgery were biochemically assayed.Result: The level of PLA 2 activity in herniated discs,ligamentum flavum and epidural fat were significantly higher than that in the normal samples ( P <0.001),and the correlation among them were satistically significant(r 1=0.6863, P =0.001;r 2=0.7388, P <0.001,r 3=0.6113, P <0.05).Conclusion: The high level of PLA 2 activity in herniated disc,ligamentum flavum and epidural fat can induce in radicular pain. |
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| Keywords: | lumbar disc herniation phospholipase A 2(PLA 2) |
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