A new role for caveolae as metabolic platforms. |
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| Authors: | Unn Ortegren Nabila Aboulaich Anita Ost Peter Str?lfors |
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| Institution: | 1. Institute for Neuroscience and Muscle Research, Children''s Hospital at Westmead, Sydney, NSW 2145, Australia;2. Discipline of Child and Adolescent Health, Faculty of Medicine, University of Sydney, Sydney, Australia;3. EMBL Australia Node in Single Molecule Science, School of Medical Science, University of New South Wales, Sydney, NSW, Australia;4. Department of Pathology and Molecular Medicine, Queen''s University, Division of Cancer Biology and Genetics, Queen''s Cancer Research Institute, Kingston, ON K7L 3N6, Canada;5. Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA;6. Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA;1. Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China;2. Shanghai Medical Imaging Institute, Shanghai, 200032, China;3. Department of Proteomics Research, College of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China;4. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China |
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| Abstract: | The plasma membrane of cells functions as a barrier to the environment. Caveolae are minute invaginations of the membrane that selectively carry out the exchange of information and materials with the environment, by functioning as organizers of signal transduction and through endocytosis. Recent findings of uptake of different metabolites and of lipid metabolism occurring in caveolae, point to a new general function of caveolae. As gateways for the uptake of nutrients across the plasma membrane, and as platforms for the metabolic conversion of nutrients, especially in adipocytes, caveolae are now emerging as active centers for many aspects of intermediary metabolism, with implications for our understanding of obesity, diabetes and other metabolic disorders. |
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