坦度螺酮治疗帕罗西汀引起男性性功能障碍的疗效观察

目的：探讨坦度螺酮对帕罗西汀引起的性功能障碍（SD）的治疗作用。方法：筛选接受帕罗西汀单药治疗维持3个月以上，进行汉密尔顿焦虑量表（HAMA，17项）、汉密尔顿抑郁量表（HAMD，17项）评分，HAMA评分＜7分和HAMD评分＜7分的康复期患者，再进行亚利桑那性经验量表（ASEX）调查，筛选出SD（ASEX总分＞19分）病例84例，再将此84例患者随机分为坦度螺酮30 mg治疗组和坦度螺酮60 mg治疗组。在治疗前、治疗4周、治疗8周后评定ASEX、国际勃起功能指数-5（IIEF-5）、改良的性生活质量调查表（mSLQQ-QoL），对比治疗前后和组间的量表得分。结果：mSLQQ-QoL总分的比较，2组患者在4周和8周时的mSLQQ-QoL总分均有明显升高，差异有统计学意义（P＜0.05）；60 mg治疗组较30 mg治疗组mSLQQ-QoL总分增加，差异有统计学意义（P＜0.01）。勃起功能障碍痊愈率的比较，30 mg治疗组痊愈率为56%，60 mg治疗组痊愈率为62.5%，2组比较差异无统计学意义（x2=0.21，P=0.64）。结论：枸橼酸坦度螺酮对帕罗西汀引起的SD具有一定治疗作用，且存在一定的量效关系。

Observation on the curative effect of tandospirone for the male sexual dysfunction induced by paroxetine

Objective: To investigate whether tandospirone can cure the male sexual dysfunction caused by paroxetine. Methods: Patients with the single treatment of paroxetine for more than 3 months were selected, evaluation of HAMA, HAMD-17 was adopted, HAMA score <7 points and HAMD score<7 points were choosed in the rehabilitation period patients, then Arizona Sexual Experience Scale (ASEX) was used. Eighty four patients whose ASEX score>19 were randomly divided into two groups, with 30 mg/d and 60 mg/d of tandospirone of each group. ASEX, IIEF-5 and sex life quality questionnaire (mSLQQ-QoL) before treatment were evaluated, treatment for 4 weeks and 8 weeks. The scale before and after treatment and the scale between groups were contrasted. Results: Compared with the total score of mSLQQ-QoL, the two groups’ total average in 4 weeks and 8 weeks all had been significantly increased (P<0.05), the two groups’ increased of total score of 30 mg/d and 60 mg/d had been significantly increased (P<0.01); comparison on the cure rate of sexual dysfunction, the 30 mg group was 56%, the 60 mg group was 62.5%, the two groups had no significant difference (x2=0.21, P=0.64). Conclusion: Tandospirone cure the sexual dysfunction caused by paroxetine has a certain therapeutic effect, and there is a certain dose-effect relationship.