蒙古扁桃药材石油醚提取物对高脂血症大鼠血脂水平的影响

目的： 研究蒙古扁桃药材石油醚提取物对高脂血症大鼠血脂水平的影响。方法：采用高脂饲料饲养5周建立高脂模型，将60只实验大鼠分成空白对照组、高脂模型组、血脂康组（61.7 mg·kg-1）、以及蒙古扁桃石油醚低、中、高剂量组（1500、2000、2500 mg·kg-1），给药7周后，眼底静脉丛取血，检测总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、低密度脂蛋白胆固醇（low density lipoprotein-C，LDL-C）、高密度脂蛋白胆固醇（high density lipoprotein-C，HDL-C），并计算血脂综合指数和动脉粥样硬化指数。结果：与高脂模型组比较，蒙古扁桃石油醚低剂量组大鼠血清中TC和LDL-C含量显著降低；血脂综合指数TC/HDL-C、LDL-C / HDL-C和动脉粥样硬化AI的比值显著降低。结论：蒙古扁桃石油醚提取物有效调节血脂水平，同时降低发生心血管疾病的危险性。

Effect of the Petroleum Ether Extract From Amygdalus Mongolica on Blood Lipid Level in Hyperlipidemia Rats

Objective：To study the effect of the petroleum ether extract from Amygdalus mongolica on blood lipid level in hyperlipidemia rats. Methods：Model was established by feeding high-fat diet for five weeks. Experimental animals were divided into six groups：control group，model group，XUE Zhi-kang group（61.7 mg·kg-1）and 1 000，2 000，2 500 mg·kg-1 of the petroleum ether extract from Amygdalus mongolica. Hyperlipidemic indicators were tested after 7 weeks oral administration of petroleum ether extract. Lipid comprehensive index and atherosclerosis index were calculated. Results：Compared with the hyperlipidemic model group，low-dose group of petroleum ether extract group from Amygdalus mongolica could significantly decreased the level of serum TC、LDL-C in the hyperlipidemia rat and TC/HDL-C、LDL-C/HDL-C、atherosclerotic index （P<0.01，P<0.05）. Conclusion：Petroleum ether extract from Amygdalus mongolica could improve blood lipid level，reduced the risk of arteriosclerosis.