CCND1 G870A基因多态性与口腔癌易感性的Meta分析

目的:采用循证医学Meta分析方法评价细胞周期蛋白D1(Cyclin D1, CCND1)基因多态性与口腔癌易感性的关联。方法:计算机检索PubMed、CBM、万方、维普、CNKI等中英文数据库,检索范围从建库至2013年7月1日,全面收集相关文献数据并计算优势比(OR)及95%置信区间(CI)以评价关联性。结果:本Meta分析共计纳入10项病例对照研究,包括1622例口腔癌患者及1859例健康对照人群。Meta分析的结果表明:CCND1 G870A基因多态性与口腔癌发病风险增加显著相关(A vs. G: OR=1.23, 95%CI: 1.02~1.49, P=0.033; AA+AG vs. GG:OR=1.39, 95%CI: 1.03~1.87, P=0.031; AA vs. AG+GG: OR=1.32, 95%CI:1.13~1.55,P=0.001; AA vs.GG:OR=1.47,95%CI:1.00~2.16, P=0.049; AA vs. AG: OR=1.22, 95%CI: 1.03~1.44, P=0.020)。亚组分析的结果进一步表明:CCND1 G870A基因多态性与口腔癌发病风险的关联性在亚洲人群和吸烟人群中尤为显著,但在高加索人群和非吸烟人群中并不显著。结论:本文提供的证据表明:CCND1 G870A基因多态性与口腔癌易感性显著相关,这一关联性在亚洲人群与吸烟人群中尤为显著。然而,CCND1 G870A基因多态性与口腔癌易感性之间的关联性,有待更大样本规模的病例对照研究加以证实。

CCND1 G870A Polymorphism Confer Susceptibility to Oral Cancer: A Meta-Analysis.

Objective: To evaluate the association of Cyclin D1 (CCND1) G870A genetic polymorphism with susceptibility to oral cancer. Methods: A literature search of PubMed, Chinese BioMedical, Wanfang, VIP, CNKI databases was conducted from inception through July 1st, 2013. Crude odd ration (OR) with 95% confidence intervals (CI) was calculated. Results: Ten case-control studies were assessed, including 1,622 oral cancer patients and 1,859 healthy controls. Meta-analysis showed that mutant A allele of CCND1 G870A polymorphism was associated with increased risk of oral cancer (A vs. G: OR=1.23, 95%CI: 1.02-1.49, P=0.033; AA+AG vs. GG: OR=1.39, 95%CI: 1.03-1.87,P=0.031; AA vs. AG+GG: OR=1.32, 95%CI: 1.13-1.55,P=0.001; AA vs. GG:OR=1.47, 95%CI: 1.00-2.16,P=0.049; AA vs. AG:OR=1.22, 95%CI: 1.03-1.44,P=0.020). Further stratified analyses indicated that this association was more significant in Asians and smokers, but not in Caucasians and non-smokers. Conclusion: This meta-analysis provides strong evidence that CCND1 G870A polymorphism may be associated with oral cancer risk, especially among Asians and smokers. However, further large-scale studies are needed to determine the association of CCND1 G870A genetic polymorphism with susceptibility to oral cancer.