阿托伐他汀治疗术后复发慢性硬膜下血肿的疗效观察

目的探讨阿托伐他汀治疗术后复发慢性硬膜下血肿的临床疗效。 方法回顾性分析襄阳市第一人民医院神经外科自2014年1月至2015年9月收治的16例慢性硬膜下血肿颅骨钻孔引流术后复发患者，采用阿托伐他汀方案治疗，观察治疗1周、2周、1个月、3个月时的患者症状、日常生活能力（ADL）评分、血肿吸收程度判断疗效。 结果治疗1周时13（13/16，81.25%）例症状减轻，15（15/16，93.75%）例ADL评分提高（P<0.05），2周左血肿开始减少（P<0.05），治疗3个月时15例症状完全改善、ADL评分恢复正常、血肿完全吸收，1例症状明显改善、ADL评分恢复正常、血肿大部分吸收，1例治疗2周时并发急性胆囊炎肝功能异常者病情加重血肿扩大，行颅骨钻孔引流术后继续服药治疗后痊愈。 结论阿托伐他汀治疗手术后复发慢性硬膜下血肿有明显效果，但对于肝功能异常者需慎重。

Effect of atorvastatin in the treatment of postoperative recurrent chronic subdural hematoma

ObjectiveTo investigate the clinical effects of atorvastatin in the treatment of postoperative recurrent chronic subdural hematoma. MethodsFrom January 2014 to September 2015, 17 patients in the first people’s hospital of xiangyang were selected as research objects. These patients received oral atorvastatin and the patient’s symptoms, daily life ability ADL score, the degree of absorption of the hematoma were observed to determine the efficacy on admission and 1th, 2th week, 1th, 3th month after the therapy. ResultsOn 1th week the symptoms improved in 13 (13/16, 81.25%) cases, ADL score increased in (15/16, 93.75%) cases (P<0.05). On 2th week the hematoma were began to reduce (P<0.05). On 3th month, ADL score returned to normal, the symptoms improved completely, and the intracranial hematoma was completely absorbed in 15 cases. ADL score returned to normal, the symptoms improved significantly, most of the intracranial hematoma was absorbed in one case. One patient complicated with acute cholecystitis and abnormal liver function, his condition deteriorated with an enlarged hematoma during the 2th week of treatment and was cured by skull drilling drainage and postoperative oral atorvastatin again. ConclusionAtorvastatin in the treatment of postoperative recurrent chronic subdural hematoma has a significant effect, but caution is needed for patients with abnormal liver function.