CXCL14在子宫内膜异位症增生期内膜中的表达

目的：分析CXCL14在子宫内膜异位症增生期在位内膜及异位内膜中的表达情况。方法：采取Real-time PCR和免疫组织化学染色法对手术和病理确诊增生期子宫内膜异位症的18例在位内膜、24例异位内膜及20例因行卵巢囊肿、子宫肌瘤手术的增生期正常子宫内膜（术后病理除外子宫内膜异位症）进行CXCL14表达的检测。结果：①与正常内膜比较，III-IV期子宫内膜异位症在位内膜的CXCL14 mRNA和蛋白表达水平明显下调，差异有统计学意义（P＜0.05）；②与正常内膜比较，I-II期子宫内膜异位症在位内膜的CXCL14 mRNA和蛋白表达水平有下调，但差异无统计学意义（P＞0.05）；③与III-IV期子宫内膜异位症在位内膜比较，III-IV期子宫内膜异位症异位内膜的CXCL14 mRNA和蛋白表达水平明显下调，差异有统计学意义（P＜0.05）；与I-II期在位内膜比较，I-II期异位内膜的CXCL14 mRNA和蛋白表达水平有下调，但差异无统计学意义（P＞0.05）。结论：CXCL14可能参与子宫内膜异位症的发生、发展，可能与子宫内膜异位症患者妊娠率低有关。

Expression of chemokine CXCL14 in the proliferative-phase endometriosis

Objective: To analyze the expression of chemokine CXCL14 in the eutopic and ectopic endometrium of the proliferative-phase endometriosis. Methods: Real-time PCR and immunohistochemistry were adopted to measure and compare the CXCL14 expression in 18 cases of eutopic endometrium, 24 cases of ectopic endometrium and 20 cases of normal endometrium, which were confirmed by surgery and pathology. Results: ①Compared to normal endometrium, the expression of chemokine CXCL14 at mRNA and protein levels significantly declined in eutopic endometrium with stage III-IV, there were significant differences (P<0.05). ②Compared to normal endometrium, the expression of chemokine CXCL14 at mRNA and protein levels declined slightly in eutopic endometrium with stage I-II, but there were no significant differences. ③The chemokine CXCL14 at mRNA and protein levels were significantly down-regulated in ectopic endometrium with stage III-IV compared to eutopic endometrium with stage III-IV (P<0.05). ④The chemokine CXCL14 at mRNA and protein levels were slightly down-regulated in ectopic endometrium with stage I-II compared to eutopic endometrium with stage I-II. Conclusion: Our findings indicated that CXCL14 may participate in the development and progression of endometriosis, which is likely associated with the low conception rates in women with endometriosis.