口腔种植手术对绝经期骨质缺乏患者血清BGP、AKP和唾液钙、磷元素的影响

目的:通过对比绝经期骨质疏松症和骨质减少症患者与正常人口腔种植手术前后血液BGP、AKP和唾液钙、磷元素变化情况,分析种植手术对上述指标的影响。方法:对74名患者按照性别、是否患有骨质疏松症、骨质减少症、是否绝经进行分组。按种植手术不同阶段,在规定时间和条件下采集唾液、血液进行实验室分析。结果:A组和B组患者血液中雌酮、雌二醇、睾酮指数低于C组,A组低于B组(P<0.05)。首诊A、B 组骨钙素(BGP)和碱性磷酸酶(AKP)高于对照组(P<0.05),A组高于B组(P<0.05)。A、B组患者术后至6个月BGP值高于首诊(P<0.05),对照组患者术后2周、3个月的BGP与首诊比较升高显著(P<0.05)。 A、B组患者唾液内钙、磷含量首诊时高于对照组,唾液内钙含量在种植后各期高于首诊值(P<0.05),对照组患者在种植后2周至3个月高于首诊值(P<0.05)。结论:绝经期患者雌激素水平降低导致的骨质疏松,使血液中BGP和AKP含量与唾液内钙、磷含量高于正常人;种植手术后唾液中钙含量的变化与BGP变化呈正相关。

Effect of Dental Implant Surgery on Levels of Serum BGP and AKP,Saliva Calcium and Phosphorus in Patients with Postmenopausal Osteoporosis

Objective: To investigate the effect of dental implant surgery on levels of serum bone gla protein (BGP), alkline phosphatase (AKP), saliva calcium, and phosphorus in patients with postmenopausal osteoporosis. Methods: Seventy-four patients were grouped according to gender and their bone quality, menopausal status. Their saliva and serum were collected at different time points. Results: The levels of estrone, estradiol, and testosterone in Group A and B were significantly lower than those of Group C (P<0.05). The levels of BGP and AKP in Group A and B were higher those of Control group (P<0.05). Dental implant surgery significantly enhanced the BGP levels. Additionally, the saliva calcium and phosphorus had the same tendency as BGP. Conclusion: Lower estrogen level in postmenopausal patients resulted in osteoporosis, and led to the increase of BGP and AKP in serum, and calcium and phosphorus in saliva compared to the control group. After dental implant surgery, the level of calcium in saliva was positively associated with the level of BGP.