甘草酸二铵联合槐耳颗粒治疗肝癌TACE术后栓塞综合征临床观察

目的：探讨甘草酸二铵联合中药槐耳颗粒治疗肝癌肝动脉化疗栓塞(TACE)术后栓塞综合征的临床疗效。 方法：选择90例肝癌行常规TACE治疗后的患者，按随机数字表法分为观察组和对照组各45例。对照组单纯给予甘草酸二铵注射治疗；观察组在对照组治疗基础上给予中药槐耳颗粒口服治疗。比较2组治疗后1个月内转氨酶和栓塞综合征缓解情况，并评价临床疗效。 结果：观察组栓塞综合征（发热、腹痛）缓解程度、生活质量评分显著高于对照组（P<0.05），观察组转氨酶复常有效率、临床总效率、术后恶心呕吐患者比例与对照组无明显差异（P>0.05）。 结论：甘草酸二铵注射联合中药槐耳颗粒治疗TACE术后栓塞综合征疗效显著，提高了患者生活质量，安全可靠，值得临床推广应用。

Clinical observation on diammonium glycyrrhizinate combined with huaier granule in the treatment of embolism syndrome after TACE therapy on hepatocellular carcinoma

Objective:To investigate the clinical effect of diammonium glycyrrhizinate combined with huaier granule in the treatment of embolism syndrome after transcatheter arterial chemoembolization (TACE) therapy on hepatocellular carcinoma. Methods:90 patients with hepatocellular carcinoma treated by TACE were randomly divided into two groups: the observation group (45 cases) and the control group (45 cases). The control group was injected with diammonium glycyrrhizinate and the observation group was given oral intake of huaier granule in addition to diammonium glycyrrhizinate injection for a month. Following that, the transaminase and remission rate of embolism syndrome were observed to compare the clinical effect of both therapies between the two groups. Results:The remission rate of embolism syndrome, total effective rate and the life quality of the observation group were significantly higher than that of the control group(P<0.05). However, there was no significant difference in lowering l transaminase of patients in both groups (P>0.05). Conclusions:Diammonium glycyrrhizinate combined with huaier granule had significant clinical effect in the treatment of embolism syndrome after TACE therapy. It is safe and can improve the patient’s life quality, and thus is worthy of clinical application.