Long term results of multimodality treatment of craniopharyngioma in children |
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| Institution: | 1. Department of Neurosurgery, The Montreal Children''s Hospital, Montreal Neurological Institute (GB), McGill University, Montréal, Québec, Canada;2. Department of Radiation Oncology, The Montreal Children''s Hospital, Montreal Neurological Institute (GB), McGill University, Montréal, Québec, Canada;1. School of Physics, University of Western Australia, Australia;2. Faculty of Health Sciences, National University of Malaysia, Bangi, Malaysia;3. Department of Radiation Oncology, Sir Charles Gairdner Hospital, Australia;4. Institute for Health Research, University of Notre Dame, Fremantle, Australia;5. Department of Physical Sciences, Peter MacCallum Cancer Centre, Melbourne, Australia;6. Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia;7. School of Surgery, University of Western Australia, Australia;8. School of Medicine and Public Health, University of Newcastle, Australia;1. Department of Neurosurgery, Ochsner Clinic Foundation, New Orleans, Louisiana, USA;2. Department of Neurosurgery, Tulane Medical Center, New Orleans, Louisiana, USA;3. Division of Neurosurgery, Department of Surgery, Jazan University, Jazan, Saudi Arabia;4. Department of Movement Disorders, Ochsner Clinic Foundation, New Orleans, Louisiana, USA;1. Division of Neurosurgery, Department of Surgery, National University Health System, Singapore;2. Division of Neurology, Department of Medicine, National University Health System, Singapore;3. Yong Loo Lin School of Medicine, National University of Singapore, Singapore |
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| Abstract: | The management of craniopharyngioma has been controversial for years. We review our 20 year experience in the treatment of paediatric craniopharyngioma. Twenty-five patients were treated for craniopharyngioma at The Montreal Children's Hospital from 1972 to 1991. They included 15 males and 10 females whose median age was 10 years. The initial clinical manifestations were remarkable for a predominance of symptoms and signs related to intracranial hypertension, followed in frequency by visual and endocrinological deficits. Radiologically, there were five cystic craniopharyngiomas, one solid and 19 mixed. Several therapeutic approaches were used including stereotactic drainage followed by radiotherapy or radiosurgery (three cases), transsphenoidal removal (six cases) and subfrontal and/or pterional craniotomy for total (three cases) or partial (13 cases) removal, followed by radiotherapy in 10 cases. The follow up period averaged 11 years. Eight patients recurred, three after total and three after partial removal; none of these six patients had received radiotherapy. Two cases treated by stereotactic drainage recurred, one received adjuvant radiosurgery and the other conventional radiotherapy. Morbidity was lower, and quality of survival better, with more conservative approaches. More conservative approaches in the management of craniopharyngioma are reasonable alternatives for treatment. Similar rates of disease control are observed with less morbidity and better quality of survival. |
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