子宫内膜癌中Survivin与EGFR的表达及其临床意义

目的：检测子宫内膜增生期内膜、不典型内膜以及内膜癌组织中存活素（Survivin）、表皮生长因子受体（EGFR）的表达，并探讨其在子宫内膜癌发生发展中的临床意义。方法：采用免疫组织化学的方法检测71例子宫内膜癌组织中Survivin、EGFR的表达，选取同期20例增生期内膜、20例不典型内膜作为对照。结果：子宫内膜癌中Survivin表达率为80.2%，EGFR表达率为52.1%，表达均较增生期内膜、不典型内膜增强。Survivin的表达与组织学分级相关；EGFR则与子宫内膜癌组织学分级以及术后死亡相关。Survivin与EGFR两者在子宫内膜癌中的表达存在正相关（r=0.048，P＜0.05）。结论：子宫内膜癌中Survivin和EGFR均存在过量表达，可能在子宫内膜癌的发生发展中起作用。两者联合检测有望用于评估子宫内膜癌的恶性程度与预后。

Expression and clinical roles of Survivin and EGFR in endometrial carcinoma

Objective: To investigate the expression of Survivin and EGFR in endometrial cancer tissues and to explore their relationship with histopathological grade, tumor stages, lymph node metastasis, etc. At last, the clinical roles of Survivin and EGFR in endometrial cancer were explored. Methods: The expressions of Survivin and EGFR were detected by immunohistochemical methods in the paraffin embedded sections of 71 endometrial cancer patients and the clinical data had been reviewed. Twenty normal endometrial tissues and 20 atypical hyperplasia endometrial tissues were chosen as control group. Results: Survivin and EGFR were over-expressed in 80.2% and 52.1% endometrial cancer specimens. The expression of Survivin was correlated to the histological grade and the expression of EGFR was correlated to the histological grade and overall survival. Over expression of Survivin and EGFR were correlated to each other. Conclusion: Both Survivin and EGFR were over-expressed in endometrial cancer specimens. Survivin and EGFR may play key roles in the development of endometrial cancer. Detection of the expression of Survivin and EGFR can be proposed in the evaluation of malignant degree and prognosis of endometrial cancer.