| 脑源性神经营养因子在中枢神经系统损伤中的多种神经保护作用及其机制的研究进展 |
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| 作者姓名： | 籍新潮 徐如祥 |
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| 作者单位： | 1. 100700 北京，陆军总医院附属八一脑科医院 |
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| 摘 要： | 中枢神经系统损伤后脑源性神经营养因子（BDNF）可以通过多种机制发挥其神经保护作用，如抑制神经元及少突胶质细胞的凋亡，促进神经突触的生长和轴突再生，促进髓鞘再生，以及调节损伤后的免疫反应和神经兴奋性等。本文主要综述了BDNF在神经保护中可能的分子机制，以进一步明确其在神经治疗中的应用价值。
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| 关 键 词： | 脑源性神经营养因子 神经保护 中枢神经系统 |
| 收稿时间： | 2015-08-17 |
Research progress of multiple neuroprotective effects of brain-derived neurotrophic factor after central nervous system injury and its mechanism |
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| Authors: | Xinchao Ji Ruxiang Xu |
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| Institution: | 1. Department of Neurosurgery, Bayi Brain Hospital Affiliated to the PLA Army General Hospital, Beijing 100700, China |
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| Abstract: | Brain-derived neurotrophic factor(BDNF) has multiple neuroprotective effects after central nervous system injury, such as inhibiting apoptosis of neurons and oligodendrocytes, promoting the growth of synapse and the regeneration of axon, promoting the regeneration of myelin sheath, adjusting the immune response and nerve excitability after injury, and so on. This article reviewed the possible molecular mechanisms of the neuroprotective effect of BDNF, in order to indentify its application value in the clinic treatment. |
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| Keywords: | Brain-derived neurotrophic factor Neuroprotection Central nervous system |
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