结直肠癌相关信号通路研究进展

结直肠癌不是一种疾病而是一系列高度异质的复杂疾病，每个患者都具有各自的遗传学和表观遗传学背景。有充分的证据提示，从正常细胞到肿瘤细胞的转化归根到底是细胞的信号调控机制发生紊乱造成的，肿瘤在形成的过程中不仅存在异常信号的转导，信号转导的异常对肿瘤的发生也似乎是必需的。目前发现与结直肠癌有关的细胞信号转导通路主要有Wnt-β-catenin信号通路、Hedgehog信号通路、Notch信号通路、TGFβ-Smads信号通路、Jak-STAT信号通路、Ras-Raf-MAPK信号通路、PI3K-Akt-mTOR信号通路。本文对结直肠癌相关信号通路的研究进展进行综述。

Research developments of the signal pathways relevant to colorectal carcinoma

Colorectal carcinoma is a series of highly heterogeneous complex diseases rather than a kind of disease. Every patient with colorectal cancer has respective genetics and epigenetics backgrounds. There is ample evidence that the transformation of cells from normal cells to tumor cells is brought about by the disorder of signal regulation mechanism. There is abnormal signal transduction in the process of tumor formation, and the disorder of signal transduction seems to be necessary in tumorigenesis. The cell signal transduction pathways relevant to colorectal cancer mainly include Wnt-β-catenin signal pathway, Hedgehog signal pathway, Notch signal pathway, TGFβ-Smads signal pathway, Jak-STAT signal pathway, Ras-Raf-MAPK signal pathway and PI3K-Akt-mTOR signal pathway. This article reviewed the research developments in the signal pathways relevant to colorectal carcinoma.