他汀类药物对慢性心力衰竭的疗效

 目的 观察他汀类药物在慢性心力衰竭(chronic heart failure,CHF)患者中的应用疗效。方法 选取100例CHF患者,纽约心功能(NYHA)分级Ⅱ至Ⅳ级,左室射血分数(LVEF )≤50%,按照是否使用他汀类药物分为观察组和对照组,每组各50例。观察并比较治疗前后两组左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)、LVEF、C反应蛋白(CRP)、低密度脂蛋白胆固醇(LDL-C)及N末端脑利钠肽前体(NT-proBNP)水平的变化及1年内住院次数及病死率。结果 观察组使用他汀药物治疗后LVESD低于对照组(50.12±4.67)mm vs (54.89±4.53)mm],LVEDD低于对照组(65.31±3.82)mm vs (68.59±4.58)mm],LVEF高于对照组(49.52±4.52)% vs (44.21±5.42)%],差异均有统计学意义(P<0.05)。与治疗前比较,观察组治疗后CRP、LDL-C及NT-proBNP降低(P＜0.05),而对照组无统计学差异。1年内观察组住院次数及病死率均低于对照组,差异有统计学意义(P＜0.05)。结论 以心血管疾病为基础疾病的CHF患者长期使用他汀类药物可明显获益。

Application of statins in patients with chronic heart failure

Objective To evaluate the effect of statins on chronic heant failure (CHF). Methods The clinical data in 100 patients with CHF from this hospital were collected, NYHA ClassⅡ-Ⅳ,and LVEF≤50%.According to whether statins were taken or not, the patients were assigned into two groups,and each group with 50 patients. The levels of left ventriculer end-dimension (LVEDD), left vewtricular end-rystohic climension(LVESD), LVEF, C-reactive protein (CRP), low-density lipoprotein cholesterol (LDL-C), NT-pro BNP, admission times and mortality were compar. Results 1. Compared with the control group, LVESD and LVEDD levels in the statins group significantly decreased (P<0.05), while LVEF was significantly increased(P<0.05).2.In the statins group, the CRP,LDL-C and NT-proBNP was dramatically decreased (P＜0.05),but there were no remarkably changes in control one.3.Admission times and mortality in two groups showed the difference(P<0.05) . Conclusions CHF based on cardiovascular disease with long-term use of statins has obvious benefit.