连体动物模型的应用

连体动物模型是通过外科手术的方式将两只动物连接起来，在伤口处发生血管再通而形成共享的循环系统，最终实现细胞和可溶性因子的交换。是一个研究循环因素影响组织器官功能的动物模型。利用异龄连体动物模型，可以观察到青年内环境影响老年小鼠的衰老表型，恢复某些衰老器官的功能；利用同龄连体模型，可以观察到相对健康的内环境对病理生理状态产生的影响。

Application of parabiosis animal model in biomedical research

The experimental model of parabiosis, which is set up through joining two animals by surgical operation, develops a common and shared circulatory system. The blood cells and soluble factors can exchange continuously at physiological levels through their intercommunicated blood circulation. The parabiosis animal model is considered as a powerful model to observe the effect of circulating factors on organisms function. In the heterochronic parabiosis model, old mice exposed to a youthful systemic milieu exhibited rejuvenated organism function. And in the isochronic parabiosis model, it was observed that relative healthy systemic milieu affected the pathophysiological process of its attached partner.