| 维生素C促进根尖牙乳头间充质干细胞组蛋白去甲基化酶KDM2B和KDM5C表达的研究 |
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| 引用本文： | 王月君,刘大勇,范志朋,贾智.维生素C促进根尖牙乳头间充质干细胞组蛋白去甲基化酶KDM2B和KDM5C表达的研究[J].口腔医学研究,2015,31(5):466. |
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| 作者姓名： | 王月君 刘大勇 范志朋 贾智 |
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| 作者单位： | 王月君1 刘大勇1 范志朋2 贾智1*(1. 天津医科大学口腔医院牙体牙髓科 天津 300070;2. 首都医科大学附属北京口腔医院 |
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| 基金项目： | 国家自然基金面上项目(编号:81371109) |
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| 摘 要： |
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| 关 键 词： | 维生素C 组蛋白去甲基化酶 根尖牙乳头间充质干细胞 KDM2B KDM5C |
| 收稿时间： | 2014-10-17 |
Vitamin C Enhanced the Expressions of Histone Demethylase KDM2B and KDM5C in Stem Cells from Apical Papilla. |
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| WANG Yue-jun,LIU Da-yong,FAN Zhi-peng,et al..Vitamin C Enhanced the Expressions of Histone Demethylase KDM2B and KDM5C in Stem Cells from Apical Papilla.[J].Journal of Oral Science Research,2015,31(5):466. |
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| Authors: | WANG Yue-jun LIU Da-yong FAN Zhi-peng |
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| Institution: | Department of Endodontics, Tianjin Medical University School of Stomatology, Tianjin 300070 |
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| Abstract: | Objective: To investigate whether Vitamin C could regulate the expression of histone demethylases in stem cells from apical papilla (SCAPs). Methods: Different doses of Vitamin C were used to stimulate the SCAPs. The qRT-PCR was used to detect the expression of histone demethylases at the mRNA level. Results: The qRT-PCR results showed that the expressions of KDM2B and KDM5C were up-regulated at 2, 4 and 8h after 10 μmol/L Vitamin C treatment in a time dependent manner. And 5, 10 and 20 μmol/L Vitamin C could increase the expressions of KDM2B and KDM5C in a dose dependent manner at 8h. Conclusion: Vitamin C could induce the expressions of histone demethylase KDM2B and KDM5C in SCAPs. |
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| Keywords: | Vitamin C Histone demethylase SCAPs KDM2B KDM5C |
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