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Angiopep-2修饰的装载不同药物的纳米系统在胶质瘤中的应用
作者姓名:苏晓梅  张丹参
作者单位:河北科技大学,石家庄,050000,中国
摘    要:脑胶质瘤是常见的原发性颅内肿瘤,其难以治愈的主要原因为血脑脊液屏障(blood-cerebrospinal fluid barrier)的存在阻碍了化疗药物进入脑内,大大降低了有效药物浓度。此外,肉眼可见的肿瘤已经处于中后期,失去了最佳的治疗时机。Angiopep-2为低密度脂蛋白受体相关蛋白(low density lipoprotein receptor related protein, LRP)的配体,血脑脊液屏障和胶质瘤细胞表面都高度表达LRP受体。Angiopep-2具有靶向性,将其修饰到装载化疗药物和显像剂的纳米粒子表面,可以实现靶向释药,提高胶质瘤成像效果。本文综述了以Angiopep-2修饰的装载不同药物的纳米系统在胶质瘤中的应用,为胶质瘤的诊断和治疗提供了思路和方法。

关 键 词:Angiopep-2    纳米递药系统    纳米成像系统    脑胶质瘤  

Application of Angiopep-2 Modified Nanoparticles Loaded With Various Drugs in Glioma
Authors:SU Xiao-mei  ZHANG Dan-shen
Institution:Hebei University of Science and Technology, Shijiazhuang, 050000, China
Abstract:Glioma is a common primary intracranial tumor, the main reason why it is difficult to cure is that the blood-cerebrospinal fluid barrier prevents the drug from crossing into the brain, thus reducing the drug effective concentration. Secondly, the visible tumor has developed to the middle or late period, missing the right treatment time. Angiopep-2 is a ligand of low density lipoprotein receptor related protein. The LRP is highly expressed on the surface of the blood-cerebrospinal fluidbarrier and glioma cells. Angiopep-2 can be modified to the surface of nanoparticles loaded with chemotherapeutic agents or imaging agents, which can achieve targeted drug delivery or significantly improve the imaging effect of glioma. This article reviews the application of the nanoparticles modified with Angiopep-2, providing some ideas and methods for the diagnosis and treatment of glioma.
Keywords:Angiopep-2  nanoparticles delivery system  nanoparticles imaging system  glioma  
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