老年男性2型糖尿病患者血浆Hcy的表达水平与骨密度的相关性分析

目的：探讨血浆同型半胱氨酸（Hcy）与老年男性2型糖尿病患者骨密度（BMD）的关系。方法：收集老年男性2型糖尿病患者45例，根据BMD水平分为骨量减少组（A组，24例）、骨量正常组（B组，21例）。检测各组患者的血浆Hcy水平、体质量指数（BMI）、血钙、血磷、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）及高密度脂蛋白胆固醇（HDL-C），2组之间进行比较。结果：A组的BMD和BMI明显低于B组，差异有统计学意义（P＜0.05）；A组的Hcy明显高于B组，差异有统计学意义（P＜0.05）；2组的血钙、血磷、TC、TG、LDL-C及HDL-C比较差异均无统计学意义（P＞0.05）；Pearson相关性分析显示，BMD与BMI呈正相关（r=0.26，P＜0.05），与Hcy呈负相关（r=-0.579，P＜0.05）。结论：BMI下降、血浆Hcy水平升高可能与老年男性2型糖尿病患者BMD的降低相关。

Association between plasma Hcy and bone mineral density in elderly male patients with type 2 diabetes mellitus

Objective: To investigate the correlation between plasma Hcy and bone mineral density (BMD) in elderly male patients with type 2 diabetes mellitus (T2DM). Methods: Forty-five elderly male patients with T2DM were divided into osteopenia group (group A, 24 patients) and normal group (group B, 21 patients) according to the level of BMD. Correlations between Hcy, body mass index (BMI), blood calcium, blood phosphorus, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were analyzed in group A and groupB. Results: BMD and BMI in group A were significantly lower than those in group B (P<0.05). Hcy in group A was significantly higher than that in group B (P<0.05). Blood calcium, blood phosphorus, TC, TG, HDL-C and LDL-C had no statistically significant difference between two groups (P>0.05). Pearson correlation analysis showed that BMD was positively correlated with BMI (r=0.26, P<0.05), and negatively correlated with Hcy (r=-0.579, P<0.05). Conclusion: The decline of BMI and incline of plasma Hcy may associate with decreasement of BMD in elderly male patients with T2DM.